Box 1.

Summary of learning points

Any breathless, hypoxic patient with cirrhosis should be checked for platypnoea and orthodeoxia at the bedside.
Hepatopulmonary syndrome is perhaps the least-recognised complication of cirrhosis.
Spider naevi represent a cutaneous marker for intrapulmonary shunting.
Hepatopulmonary syndrome is reversible and an indication for urgent liver transplantation.