Table 1.

Common drug–drug interactions with direct-acting oral anticoagulants.14

DabigatranRivaroxabanApixabanEdoxaban
Interaction effectP-glycoproteinP-glycoprotein
CYP3A4		P-glycoprotein
CYP3A4		P-glycoprotein
Increases DOAC plasma levels aDasatinibDasatinib
ImatinibImatinib
LapatinibLapatinibLapatinibLapatinib
NilotinibNilotinibNilotinibNilotinib
SunitinibSunitinibSunitinibSunitinib
TamoxifenTamoxifenTamoxifenTamoxifen
Reduces DOAC plasma levels bDexamethasoneDexamethasoneDexamethasoneDexamethasone
DoxorubicinDoxorubicinDoxorubicinDoxorubicin
EnzalutamideEnzalutamideEnzalutamideEnzalutamide
VinblastineVinblastineVinblastineVinblastine

  • DOAC = direct-acting oral anticoagulants.

  • ↵a = Drugs that inhibit P-glycoprotein or CYP3A4 can increase DOAC levels

  • ↵b = Drugs that induce P-glycoprotein or CYP3A4 can lower DOAC levels.