Skip to main content

Advertisement

Log in

Capsule Endoscopy Changes Patient Management in Routine Clinical Practice

  • Original Paper
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Our objective was to evaluate the diagnostic yield and effect of capsule endoscopy on patient management in routine clinical practice. Three hundred examinations were performed (176 females; mean age, 51 years), with a median follow-up of 17 months. Indications included overt bleeding (n = 55), anemia (n = 104), suspected Crohn’s disease (n = 68), celiac disease (n = 35), suspected functional symptoms (n = 23), polyposis (n = 5), and miscellaneous (n = 10). The overall diagnostic yield was 39%, but it was notably higher in overt bleeders, 66%, compared to 46% in the anemia group (P<0.025), 32% in the suspected Crohn’s group (P<0.001), and 17% in the functional group (P<0.001). As a result of capsule endoscopy, management was altered in 26% of patients. This study shows that capsule endoscopy has both a high diagnostic yield and an impact on subsequent patient management. These data further support the role of capsule endoscopy in routine clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adler DG, Knipschield M, Gostout C (2004) A prospective comparison of capsule endoscopy and push enteroscopy in patients with GI bleeding of obscure origin. Gastrointest Endosc 59:492–498

    Article  PubMed  Google Scholar 

  2. Appleyard M, Glukhovsky A, Swain P (2001) Wireless-capsule diagnostic endoscopy for recurrent small-bowel bleeding. N Engl J Med 344:232–233

    Article  PubMed  CAS  Google Scholar 

  3. Pennazio M, Eisen G, Goldfarb N (2005) ICCE Consensus for Obscure Gastrointestinal Bleeding. Endoscopy 37:1046–1050

    Article  PubMed  CAS  Google Scholar 

  4. Iddan GJ, Swain CP (2004) History and development of capsule endoscopy. Gastrointest Endosc Clin N Am 14:1–9

    Article  PubMed  Google Scholar 

  5. Korman LY, Delvaux M, Gay G, Hagenmuller F, Keuchel M, Friedman S, Weinstein M, Shetzline M, Cave D, de Franchis R (2005) Capsule Endoscopy Structured Terminology (CEST): proposal of a standardized and structured terminology for reporting capsule endoscopy procedures. Endoscopy 37:951–959

    Article  PubMed  CAS  Google Scholar 

  6. Catassi C, Bearzi I, Holmes GK (2005) Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology 128:S79–S86

    Article  PubMed  Google Scholar 

  7. Enns R, Go K, Chang H, Pluta K (2004) Capsule endoscopy: a single-centre experience with the first 226 capsules. Can J Gastroenterol 18:555–558

    PubMed  CAS  Google Scholar 

  8. Tatar EL, Shen EH, Palance AL, Sun JH, Pitchumoni CS (2006) Clinical utility of wireless capsule endoscopy: experience with 200 cases. J Clin Gastroenterol 40:140–144

    Article  PubMed  Google Scholar 

  9. Maieron A, Hubner D, Blaha B, Deutsch C, Schickmair T, Ziachehabi A, Kerstan E, Knoflach P, Schoefl R (2004) Multicenter retrospective evaluation of capsule endoscopy in clinical routine. Endoscopy 36:864–868

    Article  PubMed  CAS  Google Scholar 

  10. Fireman Z, Eliakim R, Adler S, Scapa E (2004) Capsule endoscopy in real life: a four-centre experience of 160 consecutive patients in Israel. Eur J Gastroenterol Hepatol 16:927–931

    Article  PubMed  Google Scholar 

  11. Qvigstad G, Hatlen-Rebhan P, Brenna E, Waldum HL (2006) Capsule endoscopy in clinical routine in patients with suspected disease of the small intestine: a 2-year prospective study. Scand J Gastroenterol 41:614–618

    Article  PubMed  Google Scholar 

  12. Rastogi A, Schoen RE, Slivka A (2004) Diagnostic yield and clinical outcomes of capsule endoscopy. Gastrointest Endosc 60:959–964

    Article  PubMed  Google Scholar 

  13. Pennazio M, Santucci R, Rondonotti E, Abbiati C, Beccari G, Rossini FP, De Franchis R (2004) Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. Gastroenterology 126:643–653

    Article  PubMed  Google Scholar 

  14. De Leusse A, Landi B, Edery J, Burtin P, Lecomte T, Seksik P, Bloch F, Jian R, Cellier C (2005) Video capsule endoscopy for investigation of obscure gastrointestinal bleeding: feasibility, results, and interobserver agreement. Endoscopy 37:617–621

    Article  PubMed  CAS  Google Scholar 

  15. Saurin JC, Delvaux M, Gaudin JL, Fassler I, Villarejo J, Vahedi K, Bitoun A, Canard JM, Souquet JC, Ponchon T, Florent C, Gay G (2003) Diagnostic value of endoscopic capsule in patients with obscure digestive bleeding: blinded comparison with video push-enteroscopy. Endoscopy 35:576–584

    Article  PubMed  Google Scholar 

  16. Kerrigan DD, Brown SR, Hutchinson GH (1990) Open access gastroscopy: too much to swallow?. BMJ 300:374–376

    Article  PubMed  CAS  Google Scholar 

  17. Kingston R, Byrnes G, O’Ceallaigh D (1999) Diagnostic yield of gastroscopy in a general surgical unit. Ir J Med Sci 168:268–270

    PubMed  CAS  Google Scholar 

  18. Wai CT, Yeoh KG, Ho KY, Kang JY, Lim SG (2002) Diagnostic yield of upper endoscopy in Asian patients presenting with dyspepsia. Gastrointest Endosc 56:548–551

    Article  PubMed  Google Scholar 

  19. Morini S, Hassan C, Meucci G, Toldi A, Zullo A, Minoli G (2001) Diagnostic yield of open access colonoscopy according to appropriateness. Gastrointest Endosc 54:175–179

    PubMed  CAS  Google Scholar 

  20. Karajeh MA, Sanders DS, Hurlstone DP (2006) Colonoscopy in elderly people is a safe procedure with a high diagnostic yield: a prospective comparative study of 2000 patients. Endoscopy 38:226–230

    Article  PubMed  CAS  Google Scholar 

  21. de Bosset V, Froehlich F, Rey JP, Thorens J, Schneider C, Wietlisbach V, Vader JP, Burnand B, Muhlhaupt B, Fried M, Gonvers JJ (2002) Do explicit appropriateness criteria enhance the diagnostic yield of colonoscopy? Endoscopy 34:360–368

    Article  PubMed  CAS  Google Scholar 

  22. Wexner SD, Garbus JE, Singh JJ (2001) A prospective analysis of 13,580 colonoscopies. Reevaluation of credentialing guidelines. Surg Endosc 15:251–261

    Article  PubMed  CAS  Google Scholar 

  23. Munitz HA, Gelfand DW, Ott DJ (1985) Upper gastrointestinal series: patient management and a study of 199 cases. Gastrointest Radiol 10:277–281

    Article  PubMed  CAS  Google Scholar 

  24. Holdsworth CD, Bardhan KD, Balmforth GV, Dixon RA, Sladen GE (1979) Upper gastrointestinal endoscopy: its effects on patient management. Br Med J 1:775–777

    Article  PubMed  CAS  Google Scholar 

  25. Hungin AP, Thomas PR, Bramble MG, Corbett WA, Idle N, Contractor BR, Berridge DC, Cann G (1994) What happens to patients following open access gastroscopy? An outcome study from general practice. Br J Gen Pract 44:519–521

    PubMed  CAS  Google Scholar 

  26. Graham DJ, Pritchard TJ, Bloom AD (1993) Colonoscopy for intermittent rectal bleeding: impact on patient management. J Surg Res 54:136–139

    Article  PubMed  CAS  Google Scholar 

  27. Mata A, Bordas JM, Feu F, Gines A, Pellise M, Fernandez-Esparrach G, Balaguer F, Pique JM, Llach J (2004) Wireless capsule endoscopy in patients with obscure gastrointestinal bleeding: a comparative study with push enteroscopy. Aliment Pharmacol Ther 20:189–194

    Article  PubMed  CAS  Google Scholar 

  28. Kalantzis N, Papanikolaou IS, Giannakoulopoulou E, Alogari A, Kalantzis C, Papacharalampous X, Gabriel P, Alexandrakis G, Apostolopoulos P (2005) Capsule endoscopy; the cumulative experience from its use in 193 patients with suspected small bowel disease. Hepatogastroenterology 52:414–419

    PubMed  CAS  Google Scholar 

  29. Selby W (2004) Can clinical features predict the likelihood of finding abnormalities when using capsule endoscopy in patients with GI bleeding of obscure origin? Gastrointest Endosc 59:782–787

    Article  PubMed  Google Scholar 

  30. Viazis N, Papaxoinis K, Theodoropoulos I, Sgouros S, Vlachogiannakos J, Pipis P, Markoglou C, Avgerinos A (2005) Impact of capsule endoscopy in obscure small-bowel bleeding: defining strict diagnostic criteria for a favorable outcome. Gastrointest Endosc 62:717–722

    Article  PubMed  Google Scholar 

  31. Kitiyakara T, Selby W (2005) Non-small-bowel lesions detected by capsule endoscopy in patients with obscure GI bleeding. Gastrointest Endosc 62:234–238

    Article  PubMed  Google Scholar 

  32. Zaman A, Katon RM (1998) Push enteroscopy for obscure gastrointestinal bleeding yields a high incidence of proximal lesions within reach of a standard endoscope. Gastrointest Endosc 47:372–376

    Article  PubMed  CAS  Google Scholar 

  33. Hayat M, Axon AT, O’Mahony S (2000) Diagnostic yield and effect on clinical outcomes of push enteroscopy in suspected small-bowel bleeding. Endoscopy 32:369–372

    Article  PubMed  CAS  Google Scholar 

  34. Lewis BS, Eisen GM, Friedman S (2005) A pooled analysis to evaluate results of capsule endoscopy trials. Endoscopy 37:960–965

    Article  PubMed  CAS  Google Scholar 

  35. Bardan E, Nadler M, Chowers Y, Fidder H, Bar-Meir S (2003) Capsule endoscopy for the evaluation of patients with chronic abdominal pain. Endoscopy 35:688–689

    Article  PubMed  CAS  Google Scholar 

  36. Fleischer W, Leighton J, Sharma V, Heigh R (2003) Video capsule endoscopy is useful in the evaluation of patients with chronic abdominal pain. Gastroenterology 124:A245 (abstract)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Reena Sidhu.

Additional information

R.S. wrote the initial draft; all five authors were involved in the subsequent revisions and final draft. M.E.M. is the guarantor for this paper.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sidhu, R., Sanders, D.S., Kapur, K. et al. Capsule Endoscopy Changes Patient Management in Routine Clinical Practice. Dig Dis Sci 52, 1382–1386 (2007). https://doi.org/10.1007/s10620-006-9610-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-006-9610-6

Keywords

Navigation