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The relationship between depression and erectile dysfunction

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Abstract

Normal sexual function is a biopsychosocial process; sexual dysfunction almost always has organic and psychologic components, and it requires multidisciplinary, goal-directed evaluation and treatment. Factors such as aging, declining testosterone levels, medical illness, certain medications, and comorbid depressive illness can contribute to sexual dysfunction. Erectile dysfunction (ED) is the most common male sexual dysfunction encountered in the clinical setting. Comorbidity between ED and depressive illness is high, but the causal relationship is unclear, and likely bidirectional. In this article, we review the existing literature on the relationship between depression and ED.

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References and Recommended Reading

  1. Feldman HA, Goldstein I, Hatzichristou G, et al.: Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994, 151:73–80.

    Google Scholar 

  2. NIH Consensus Panel on Impotence: Impotence. JAMA 1993, 270:83-90.

  3. Thase ME, Reynolds CF, Jennings R, et al.: Nocturnal penile tumescence is diminished in depressed men. Biol Psychiatry 1988, 24:33–46.

    Article  PubMed  CAS  Google Scholar 

  4. Reynolds CF III, Frank E, Thase ME, et al.: Assessment of sexual function in depressed, impotent, and healthy men: factor analysis of a brief sexual function questionnaire for men. Psychiatry Res 1988, 24:231–250.

    Article  PubMed  Google Scholar 

  5. Roose SP, Glassman AH, Walsh BT, Cullen K: Reversible loss of nocturnal penile tumescence during depression: a preliminary report. Neuropsychobiology 1982, 8:284–288.

    Article  PubMed  CAS  Google Scholar 

  6. Mathew RJ, Weinman ML: Sexual dysfunctions in depression. Arch Sex Behav 1982, 11:323–328.

    Article  PubMed  CAS  Google Scholar 

  7. Blazer DG, Kessler RC, McGonagle KA, Swartz MS:The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey. Am J Psychiatry 1994, 151:979–986.

    PubMed  CAS  Google Scholar 

  8. Devanand DP, Nobler MS, Singer T, et al.: Is dysthymia a different disorder in the elderly? Am J Psychiatry 1994, 151:1592–1599.

    PubMed  CAS  Google Scholar 

  9. Blazer DG, Hughes DC, George LK: The epidemiology of depression in an elderly community population. Gerontologist 1987, 27:281–287.

    PubMed  CAS  Google Scholar 

  10. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: edn 4, revised. Washington, DC: American Psychiatric Association; 1994:100-102.

  11. Seidman SN, Rieder RO: Sexual behavior through the life cycle: an empirical approach. In American Psychiatric Press Review of Psychiatry, vol 14. Edited by Oldham J, Riba M. Washington, DC: American Psychiatric Press; 1995:639–676.

    Google Scholar 

  12. Mulligan T, Retchin SM, Chinchilli VM, et al.: The role of aging and chronic disease in sexual dysfunction. J Am Geriatr Soc 1988, 36:520–524.

    PubMed  CAS  Google Scholar 

  13. Seidman SN, Walsh BT: Testosterone and depression in aging men. Am J Geriatr Psychiatry 1999, 7:18–33. This paper reviews the relationship between major depressive disorder and testosterone level, as well as treatment with exogenous testosterone.

    PubMed  CAS  Google Scholar 

  14. Gitlin MJ: Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches. J Clin Psychiatry 1994, 55:406–413.

    PubMed  CAS  Google Scholar 

  15. Ashton AK, Hamer R, Rosen RC: Serotonin reuptake inhibitorinduced sexual dysfunction and its treatment: a largescale retrospective study of 596 psychiatric outpatients. J Sex Marital Ther 1997, 23:165–175.

    Google Scholar 

  16. Balon R, Yeragani VK, Pohl R, et al.: Sexual dysfunction during antidepressant treatment. J Clin Psychiatry 1993, 54:209–212.

    PubMed  CAS  Google Scholar 

  17. Steiger A, Holsboer F, Bunkert O: Studies of nocturnal penile tumescence and sleep electroencephalogram in patients with major depression and in normal controls. Acta Psychiatr Scand 1993, 87:358–363.

    Article  PubMed  CAS  Google Scholar 

  18. Thase ME, Reynolds CF III, Jennings RJ, et al.: Diminished nocturnal penile tumescence in depression: a replication study. Biol Psychiatry 1992, 31:1136–1142.

    Article  PubMed  CAS  Google Scholar 

  19. Araujo AB, Durante R, Feldman HA, et al.: The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med 1998, 60:458–465. This paper establishes the strong epidemiologic relationship between ED (using reliable criteria) and depression (using CES-D cutoff > 16).

    PubMed  CAS  Google Scholar 

  20. Derogatis LR, Meyer JK, King KM: Psychopathology in individuals with sexual dysfunction. Am J Psychiatry 1981, 138:757–763.

    PubMed  CAS  Google Scholar 

  21. Fagan PJ, Schmidt CW, Wise TN, et al.: Sexual dysfunction and dual psychiatric diagnoses. Comp Psychiatry 1988, 29:278–284.

    Article  CAS  Google Scholar 

  22. Jonler M, Moon T, Brannan W, et al.: The effect of age, ethnicity and geographical location on impotence and quality of life. Br J Urol 1995, 75:651–655.

    Article  PubMed  CAS  Google Scholar 

  23. Willke RJ, Glick HA, McCarron TJ, et al.: Quality of life effects of alprostadil therapy for erectile dysfunction. J Urol 1997, 157:2124–2128.

    Article  PubMed  CAS  Google Scholar 

  24. Padma-Nathan H, Hellstrom WJG, Kaiser FE, et al.: Treatment of men with erectile dysfunction with transurethral alprostadil. N Engl J Med 1997, 336:1–7.

    Article  PubMed  CAS  Google Scholar 

  25. Althof SE, Turner LA, Levine SB, et al.: Through the eyes of women: the sexual and psychological responses of women to their partner’s treatment with self-injection or external vacuum therapy. J Urol 1992, 147:1024–1027.

    PubMed  CAS  Google Scholar 

  26. van Driel MF, Mooibroek JJ, van de Wiel HBM, et al.: Intracavernous pharmacotherapy: psychological, sexological and medical aspects. Int J Impot Res 1991, 3:95–104.

    Google Scholar 

  27. Steers W, for the Sildenafil Study Group: Meta-analysis of the efficacy of sildenafil (VIAGRA) in the treatment of severe erectile dysfunction. J Urol 1998, 159(suppl):238.

    Google Scholar 

  28. Morales A, Gingell JC, Collins M, et al.: Clinical safety of oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction. Int J Impot Res 1998, 10:69–74.

    Article  PubMed  CAS  Google Scholar 

  29. Shabsigh R, Klein LT, Seidman S, et al.: Increased incidence of depressive symptoms in men with erectile dysfunction. Urology 1998, 52:848–852.

    Article  PubMed  CAS  Google Scholar 

  30. Price D: Sildenafil citrate (Viagra) efficacy in the treatment of erectile dysfunction in patients with common concomitant conditions. Int J Clin Pract 1999, 102(suppl):S21-S23.

    Google Scholar 

  31. Seidman S, Rosen R, Roose SP, et al.: Sildenafil citrate for erectile dysfunction and depression. XI World Congress of Psychiatry, Hamburg, Germany, August, 1999.

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Seidman, S.N., Roose, S.P. The relationship between depression and erectile dysfunction. Curr Psychiatry Rep 2, 201–205 (2000). https://doi.org/10.1007/s11920-996-0008-0

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