Clinical communicationT-wave abnormalities during hyperventilation and isoproterenol infusion☆
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2002, Journal of the American College of CardiologyCitation Excerpt :In contrast to the other states investigated, isoproterenol infusion is not associated with significant vagal withdrawal. Interestingly, previous studies have been inconsistent with regard to the effect of isoproterenol on QT (21,23), likely reflecting differences in QT measurement methodology, treatment of U-waves and duration of adrenergic exposure (24,25), all of which could produce important effects on the measurement of QT duration. Studies using various cardiac myocyte preparations have reported both increased (5,6,26,27)and decreased (6,26,28)action potential duration with isoproterenol.
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Supported by National Institutes of Health Research Grant HE 07359 and by National Institutes of Health Training Grant HE 05598.
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United States Public Health Service Research Fellow (HE 35651).
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Research Associate.
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Professor of Medicine, Director of Cardiovascular Division.