Clinical studyComparison of internal mammary artery ligation and sham operation for angina pectoris∗☆
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2023, Progress in Cardiovascular DiseasesMyocardial Revascularization Surgery: JACC Historical Breakthroughs in Perspective
2021, Journal of the American College of CardiologyCitation Excerpt :In 1939, Davide Fieschi was the first to ligate the RIMA, a procedure which was subsequently modified to bilateral IMA (BIMA) ligation with initial reports of nearly universal efficacy for relief of angina (9). However, early enthusiasm was dampened by 2 randomized trials that demonstrated no difference in symptomatic improvement among patients undergoing BIMA ligation versus those who underwent sham procedures (10,11). In 1946, Arthur Vineberg performed his eponymously named procedure in which the LIMA was “transplanted” into the anterior wall of the left ventricle, adjacent to the left anterior descending artery (LAD) but without creating a surgical anastomosis (12).
Effect of permanent right internal mammary artery occlusion on right coronary artery supply: A randomized placebo-controlled clinical trial
2020, American Heart JournalCitation Excerpt :Before the advent of coronary bypass surgery, the ligation of the IMAs aiming at redirecting blood flow to the pericardiacophrenic branch was introduced as a treatment concept for angina pectoris by Fieschi.29 Following initial documentation of clinical success,30 surgical IMA ligation has been reported inefficacious based on 2 very small (totaling 35 patients) but sham-controlled clinical trials,31,32 the publication of which together with the advent of the heart-lung machine closed this option of myocardial revascularization almost entirely. The physical basis of action of IMA ligation, flow diversion toward its side branches connecting to the heart, persisted only in the Vineberg procedure with its direct implantation of the disconnected IMAs into the freely exposed myocardium.
Improving the Design of Future PCI Trials for Stable Coronary Artery Disease: JACC State-of-the-Art Review
2020, Journal of the American College of CardiologyPain, placebo, and test of treatment efficacy: a narrative review
2019, British Journal of AnaesthesiaCitation Excerpt :Creating a placebo control for an open surgery is much more challenging as it would require a large skin incision and this is one of the reasons why, after the internal mammary artery ligation trials in the 1950s and 1960s, open surgery trials with placebo control have not been attempted.104 The first surgical placebo-controlled trials were performed by Cobb and colleagues (1959)108 and by Dimond and colleagues (1960)109 to test the efficacy of the internal mammary artery ligation on symptoms of coronary heart disease. In these studies, some patients had a placebo procedure, that is, a skin incision, instead of the surgical procedure changing vasculature to provide additional blood supply to the coronary vessels.
Biostatistics Manual for Health Research: A Practical Guide to Data Analysis
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This study was aided in part by grants from the Kansas Heart Association and the National Heart Institute (HTS-5210 [C1]).