Elsevier

The Lancet

Volume 340, Issue 8833, 12 December 1992, Pages 1444-1447
The Lancet

SCIENCE & PRACTICE
Pathophysiology of the irritable bowel syndrome

https://doi.org/10.1016/0140-6736(92)92631-OGet rights and content

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  • Cited by (29)

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      In subsequent years, Christensen14 even questioned the existence of IBS as a distinct entity. Nevertheless his belief that “heterogeneity of pathological processes must exist in such a diagnostic category”15 opened the door to research that later identified meaningful biological subsets of IBS or, alternatively, disorders considered distinctly separate from IBS. It also led investigators to consider alternative conceptualizations for the symptoms of IBS relating to a more integrative multicomponent model as discussed later.

    • Medical management of diverticular disease

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    • Visceral afferent hypersensitivity in irritable bowel syndrome - Evaluation by cerebral evoked potential after rectal stimulation

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      It has variously been attributed to deficiency of dietary fiber (1, 2), gut infections (3, 4), GI dysmotility (5–7), stressful life events (8–10) and psychopathology (11, 12). However, none of these adequately explains the diverse symptomatology and physiological alterations seen in IBS (13). Abnormal visceral perception has recently been proposed to underlie the observed heightened visceral sensitivity in IBS, other functional GI disorders and noncardiac chest pain.

    • Irritable bowel syndrome: Making sense of it all

      1999, Bailliere's Best Practice in Clinical Gastroenterology
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