Predictors of lymphoma development in primary Sjögren's syndrome

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Abstract

Objective:

To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS).

Methods:

Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied.

Results:

Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associatedlymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development.

Conclusion:

Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.

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    1

    Dr. Inanc was a visiting research fellow from the University ofIstanbul, Istanbul, Istanbul Faculty of Medicine. His work was supported partially by the European Scientific Exchange Programme (Royal Society) and the NATO B-2 Postdoctoral Research Programme, both awarded by the Scientific and Technical Research Council of Turkey (TUBITAK).

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