Arrhythmias and conduction disturbanceDiagnostic and Prognostic Value of a Type 1 Brugada Electrocardiogram at Higher (Third or Second) V1 to V2 Recording in Men With Brugada Syndrome
Section snippets
Methods
The study population consisted of 98 probands from 98 unrelated families in whom a type 1 Brugada ECG was documented in leads V1 and V2 at a standard (fourth) and/or higher (third or second) intercostal space in the absence or presence of class Ic sodium channel blockers. They were enrolled between October 2000 and September 2004 and were followed prospectively. All 98 patients were men. Their average age at enrollment was 47 ± 13 years (17 to 76). VF had been documented in 22 men and 32 had
Results
Table 1 presents a comparison of clinical, electrocardiographic, and electrophysiologic characteristics across the S group (spontaneous only), H group (spontaneous only), and Ic group. There were no significant differences in baseline clinical characteristics with respect to gender, age, frequency of documented episodes of VF and syncope, family history (sudden cardiac death or a Brugada ECG), late potential, atrial fibrillation, and inducibility of VF/ventricular tachycardia during the
Discussion
The major findings of our study were that (1) recording at a higher space in leads V1 and V2 had higher sensitivity than that at a standard space in these leads in detecting a type 1 Brugada ECG and (2) a type 1 Brugada ECG recorded only at a higher space in leads V1 and V2 showed a similar prognostic value for subsequent cardiac events as that recorded at a standard space in these leads.
Priori et al9 reported that only 50% of patients with Brugada syndrome in whom repetitive baseline ECGs were
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Dr. Shimizu was supported by the Hoansha Research Foundation, Japan Research Foundation for Clinical Pharmacology, Ministry of Education, Culture, Sports, Science and Technology Leading Project for Biosimulation, and Health Sciences Research Grants (H18, Research on Human Genome, 002) from the Ministry of Health, Labour and Welfare, Tokyo, Japan.