MiscellaneousPrognosis of Idiopathic Recurrent Pericarditis as Determined from Previously Published Reports
Section snippets
Methods and Results
To reflect the best available evidence, we performed a comprehensive Medline search of all publications from 1966 to 2006 with the MeSH terms “pericarditis,” “recurrent pericarditis,” “pericardial constriction,” and “cardiac tamponade.” Additional publications were sought using the reference lists of identified papers, the published reviews on the topic, and a search of abstracts from the scientific sessions of the American College of Cardiology, the American Heart Association, and the European
Discussion
A systematic review of all publications on recurrent pericarditis shows that the overall life prognosis is excellent in idiopathic recurrent pericarditis, and complications are uncommon. Despite the common concern for the risk of constriction, constrictive pericarditis was never reported in these patients despite numerous recurrences, and the overall risk is lower than in idiopathic acute pericarditis (approximately 1%).3 Thus, it is important to reassure patients on their prognosis, explaining
References (20)
- et al.
Recurrent acute pericarditis: follow-up study of 31 patients
J Am Coll Cardiol
(1986) - et al.
Immunosoppressive therapy prevents recurrent pericarditis
J Am Coll Cardiol
(1995) - et al.
Recurrent pericarditis in children and adolescents
J Am Coll Cardiol
(2003) - et al.
Management, risk factors, and outcomes in recurrent pericarditis
Am J Cardiol
(2005) - et al.
Long-term outcomes in difficult-to-treat patients with recurrent pericarditis
Am J Cardiol
(2006) - et al.
Recurrent pericarditic pain without objective evidence of disease in patients with previous acute pericarditis
Am J Cardiol
(2004) - et al.
Azatioprine therapy of steroid-responsive pericarditis
Am Heart J
(1970) - et al.
Colchicine treatment for recurrent pericarditisA decade of experience
Circulation
(1998) - et al.
Guidelines on the Diagnosis and Management of Pericardial Diseases
Eur Heart J
(2004) - et al.
Relapsing pericarditis
Heart
(2004)
Cited by (91)
New Developments in the Management of Recurrent Pericarditis
2023, Canadian Journal of CardiologyA systematic review and meta-analysis of randomized controlled trials evaluating pharmacologic therapies for acute and recurrent pericarditis
2023, Trends in Cardiovascular MedicineRecurrent pericarditis
2021, Medicine (Spain)Constrictive pericarditis
2021, Medicine (Spain)RHAPSODY: Rationale for and design of a pivotal Phase 3 trial to assess efficacy and safety of rilonacept, an interleukin-1α and interleukin-1β trap, in patients with recurrent pericarditis
2020, American Heart JournalCitation Excerpt :Colchicine is also associated with intolerability and potentially serious adverse effects due to its narrow therapeutic index. A significant proportion of patients is treated with long-term CSs in an effort to maintain disease control and to prevent future recurrences, but the long-term morbidity associated with toxicity from chronic CS use is well established and adds to the overall burden of this disease, and a meta-analysis of 4 observational studies (378 patients) showed that CS use increased the risk of RP and recurrences.19 The need for safer, well-tolerated, targeted, CS-sparing therapies was the impetus for rilonacept development in recurrent pericarditis and the conduct of RHAPSODY as a pivotal, Phase 3, multinational trial.
Tuberculous and Infectious Pericarditis
2017, Cardiology ClinicsCitation Excerpt :Viral pericarditis is self-limiting in most cases and rarely leads to cardiac tamponade or constrictive pericarditis. However, progression to tamponade might occur in high-risk patients.28 Recurrence rates after an initial episode of viral or idiopathic pericarditis ranges from 15% to 30%,29,30 and most recurrences are associated with inadequate treatment of the first pericarditis episode.