Clinical research studyMortality after Hospitalization with Mild, Moderate, and Severe Hyponatremia
Section snippets
Source Population
We extracted administrative and laboratory data from individuals admitted to 2 academic teaching hospitals in Boston, Massachusetts. Brigham and Women's Hospital (BWH) is a 777-bed teaching hospital. Massachusetts General Hospital (MGH) is a 902-bed teaching hospital. The 2 hospitals provide primary as well as tertiary care to an ethnically and socioeconomically diverse population within eastern Massachusetts and the surrounding region.
Data Sources
Data on all patients admitted for at least 48 hours to BWH
Clinical Characteristics
Among 98,411 individuals admitted during the study period, hyponatremia (serum sodium concentration <135 mEq/L) was present on the first sodium determination in 14,290 (14.5%) and at some point during hospitalization in an additional 5093 (total, 19.7%). Hyponatremia on admission was mild (130-134 mEq/L) in the majority of patients (83.0%) and severe (<120) in only 0.2% (Table 1).
Hyperglycemia (glucose ≥200 mg/dL) was present in 15.8% of patients admitted with hyponatremia (glucose was measured
Discussion
The prevalence of hyponatremia (first measured serum sodium concentration <135 mEq/L) in individuals hospitalized for at least 2 days is approximately 13%. Our estimate is higher than the 5.5% prevalence reported in the 39-hospital study by Zilberberg et al,5 which included all admissions irrespective of length of stay. Anderson et al12 found a prevalence of 2.4% when defining hyponatremia as serum sodium concentration <130 mEq/L; our results using this definition are similar. Our study
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Funding: Investigator-initiated grant from Astellas Pharma US, Inc.
Conflict of Interest: Dr. Mount reported receiving lecture fees from Astellas Pharma, US, Inc. Astellas had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Authorship: Dr. Waikar had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.