Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 11, November 2011, Pages 1557-1566
ReviewGenetic modifiers of non-alcoholic fatty liver disease progression
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Highlights
► NAFLD/NASH is a common, progressive liver disease. ► Subtle inter-patient genetic variation and environment influence disease progression. ► GWAS and candidate gene studies have identified several genetic modifiers. ► Polymorphisms in PNPLA3 have been identified and replicated in several studies. ► Understanding the genetic basis of disease will suggest novel therapeutic targets.
Keywords
NAFLD
NASH
Steatohepatitis
Gene
Polymorphism
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