ReviewWhy does chronic inflammation persist: An unexpected role for fibroblasts
Section snippets
Background
Two characteristic features of chronic inflammatory reactions are their persistence and predilection for certain sites. Why for example do some forms of inflammation resolve, yet others do not? Why does arthritis localize predominantly to the joints compared to psoriasis which localizes predominantly to the skin? It has been assumed that inflammation is a stereotyped response that reflects a common or “public” set of shared pathways leading to endothelial cell activation, leukocyte infiltration
Concluding remarks
Immune cells need to interact with a wide variety of cell types both within immune (lymphoid) and peripheral tissues. During inflammation, stromal cells such as fibroblasts, become activated and interact with infiltrating immune cells in a dynamic and site-specific manner. Populations of leukocytes recruited to sites of inflammation should not be considered in isolation, but in conjunction with the non-immune cells that help provide survival, differentiation and positional cues upon which the
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