The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy☆,☆☆
Section snippets
Research design and methods
A pre-test post-test design was used for this pilot study, with all subjects participating in the intervention. This study was approved by the Human Subjects Committee/Institutional Review Board of the University of Kansas Medical Center.
Subjects
Informed consent forms were signed by 30 individuals, and 19 subjects completed the intervention. Three subjects were disqualified during baseline testing because of health issues that prevented participation in the exercise test (n = 2) or the absence of neuropathic signs or symptoms (n = 1). Six subjects withdrew before starting the intervention because of schedule conflicts or transportation issues. Two subjects withdrew because of the onset of medical issues that interfered with exercise
Conclusions
This is the first study to describe improvements in outcomes related to neuropathic symptoms and cutaneous nerve fiber branching following supervised exercise in people with diabetic peripheral neuropathy. The exercise intervention was feasible for the subject participants screened using the study criteria, as the study was completed by 63.3% of subjects who signed the consent form, and no serious unanticipated adverse events occurred with maximal or submaximal levels of exercise.
Despite the
Acknowledgments
The authors thank the following individuals who assisted with supervising the exercise intervention: Benjamin Tseng, Rachel Moses, Kayla Buehler, and Jennifer Jones, University of Kansas Medical Center. We would also like to thank Janelle Ryals, University of Kansas Medical Center, who processed and quantified the skin biopsy tissue, and Laura Herbelin, University of Kansas Medical Center, who assisted with the nerve conduction studies and quantitative sensory testing. Dr. Mazen DiMachkie,
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Conflict of Interest: The authors have no conflict of interest to disclosure.
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NCT00970060, ClinicalTrials.gov.