Original articleIncreased Incidence of Cutaneous Nontuberculous Mycobacterial Infection, 1980 to 2009: A Population-Based Study
Section snippets
Patients and Methods
After approval by the institutional review boards of Olmsted Medical Center and Mayo Clinic, we collected inpatient and outpatient medical records of residents of Olmsted County from the Rochester Epidemiology Project (REP). The REP is an informatics tool that indexes medical diagnoses made at health care facilities (clinics, hospitals, and nursing homes) or during autopsies for all residents of Olmsted County.
Using the REP database, we retrieved all the medical records for Olmsted County
Results
A search of the REP database yielded 360 medical records of patients identified as having any form of NTM infection. Records were excluded if infections (1) were not cutaneous or (2) did not meet the inclusion criteria of positive growth in culture concomitant with 1 or more correlated clinical signs. Forty cases of definite SSTI caused by NTM were reviewed and analyzed.
Infections were recorded in 23 female patients (58%) and 17 male patients (43%). The median age of the 40 patients was 47
Discussion
The results of this study show that in Olmsted County, the incidence of cutaneous NTM infection in 2000 to 2009 (2.0 per 100,000 person-years) was nearly 3-fold higher than that in 1980 to 1999 (0.7 per 100,000 person-years). This finding provides population-based data to substantiate the presumed increased incidence of cutaneous NTM infection. This report based case definition on culture and clinical data rather than on laboratory results alone.10
During the entire study period, M marinum was
Conclusion
The incidence of cutaneous NTM infection has increased nearly 3-fold in Olmsted County during the past 30 years, from 0.7 per 100,000 person-years between 1980 and 1999 to 2.0 per 100,000 person-years between 2000 and 2009. There was no significant difference between males and females in the rate of NTM infection, although the incidence did increase with age. The RGM infections made up the greatest proportion of cases in the latter third of the study's time frame, caused all cases of infection
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Grant Support: This study was made possible by the Rochester Epidemiology Project (Principal Investigators: Walter A. Rocca, MD, MPH, and Barbara P. Yawn, MD, MSc). Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.