Elsevier

Kidney International

Volume 77, Issue 4, 2 February 2010, Pages 299-311
Kidney International

Review
KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary

https://doi.org/10.1038/ki.2009.377Get rights and content
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The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on the monitoring, management, and treatment of kidney transplant recipients is intended to assist the practitioner caring for adults and children after kidney transplantation. The guideline development process followed an evidence-based approach, and management recommendations are based on systematic reviews of relevant treatment trials. Critical appraisal of the quality of the evidence and the strength of recommendations followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach. The guideline makes recommendations for immunosuppression and graft monitoring, as well as prevention and treatment of infection, cardiovascular disease, malignancy, and other complications that are common in kidney transplant recipients, including hematological and bone disorders. Limitations of the evidence, especially the lack of definitive clinical outcome trials, are discussed and suggestions are provided for future research. This summary includes a brief description of methodology and the complete guideline recommendations but does not include the rationale and references for each recommendation, which are published elsewhere.

Keywords

disease management
KDIGO
kidney transplantation
practice guideline
systematic review

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KDIGO makes every effort to avoid any actual or reasonably perceived conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the Work Group. All members of the Work Group are required to complete, sign, and submit a disclosure and attestation form showing all such relationships that might be perceived or actual conflicts of interest. This document is updated annually and information is adjusted accordingly. All reported information is printed in the full version publication of the guideline and is on file at the National Kidney Foundation (NKF), Managing Agent for KDIGO. Bertram L. Kasiske, MD (Work Group Co-Chair) has served as an Advisor/Consultant for Astellas, LithoLink, Novartis, and Wyeth. He has received Grant/Research support from Bristol–Myers Squibb, Genzyme, and Merck-Schering Plough. Martin G. Zeier, MD, FASN (Work Group Co-Chair) has received Grant/Research support from Astellas, Novartis, and Parexel. Jeremy R. Chapman, MD, FRACP, FRCP has served as an Advisor/Consultant for Astellas, Hoffmann-LaRoche, Novartis, and Wyeth. He has Grant/Research support from Bristol-Myers Squibb, Novartis, and Wyeth. Henrik Ekberg, MD, PhD has served as an Advisor/Consultant for Astellas, Bristol-Myers Squibb, Hoffmann-LaRoche, Life Cycle Pharma, Novartis, and Wyeth. He has also served as Speaker for Astellas and Hoffmann-LaRoche. Michelle A. Josephson, MD has served as an Advisor/Consultant for Digitas Health, MKSAP and Wyeth. She has also served as Speaker for Hoffmann-LaRoche and has received Grant/Research Support from Amgen, Astellas, and Wyeth. Bryce A. Kiberd, MD has served as Speaker for Hoffmann-LaRoche. Henri A. Kreis, MD has served as an Advisor/Consultant for Novimmune. John M. Newmann, PhD, MPH has served as an Advisor/Consultant for Arbor Research Collaborative and Renaissance Health Care. Flavio G. Vincenti, MD has received Grant/Research support from Astellas, Bristol-Myers Squibb, Genentech, Hoffmann-LaRoche, Novartis, and Wyeth.

The following individuals reported no relevant financial relationships: Samuel Abariga, MD, MS; Ethan M. Balk, MD MPH; Michael Cheung, MA; Jonathan Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhD; Amy Earley, BS; Catherine A. Garrey, RN, BA, CCTC; Michael D. Green, MD, MPH; Vivekanand Jha, MD, FRCP; Ruth A. McDonald, MD; Gregorio T. Obrador, MD, MPH; Gowri Raman, MD; and Martin Wagner, MD, MS.