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Educating health-care professionals about genetics and genomics

Abstract

To biomedical researchers, this is the 'genome era'. Advances in genetics and genomics such as the sequence of the human genome, the human haplotype map, open access databases, cheaper genotyping and chemical genomics have already transformed basic and translational biomedical research. However, for most clinicians, the genome era has not yet arrived. For genomics to have an effect on clinical practice that is comparable to its impact on research will require advances in the genomic literacy of health-care providers. Here we describe the knowledge, skills and attitudes that genomic medicine will require, and approaches to integrate them into the health-care community.

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References

  1. Jarvinen, H. J. et al. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 118, 829–834 (2000).

    Article  CAS  Google Scholar 

  2. Winegarden, N. Microarrays in cancer: moving from hype to clinical reality. Lancet 362, 1428 (2003).

    Article  Google Scholar 

  3. Relling, M. V. et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J. Natl Cancer Inst. 91, 2001–2008 (1999).

    Article  CAS  Google Scholar 

  4. Sconce, E. A. et al. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 106, 2329–2333 (2005).

    Article  CAS  Google Scholar 

  5. Kumar, P., Radhakrishnan, J., Chowdhary, M. A. & Giampietro, P. F. Prevalence and patterns of presentation of genetic disorders in a pediatric emergency department. Mayo Clin. Proc. 76, 777–783 (2001).

    Article  CAS  Google Scholar 

  6. Beutler, E. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood 101, 47–50 (2003).

    Google Scholar 

  7. Fry, A. et al. GPs' views on their role in cancer genetics services and current practice. Fam. Pract. 16, 468–474 (1999).

    Article  CAS  Google Scholar 

  8. World Health Organization. Genomics and world health: report of the Advisory Committee on Health Research [online], (2002).

  9. Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498–511 (2002).

    Article  CAS  Google Scholar 

  10. Holt, R. A. et al. The genome sequence of the malaria mosquito Anopheles gambiae. Science 298, 129–149 (2002).

    Article  CAS  Google Scholar 

  11. Coppel, R. L., Roos, D. S. & Bozdech, Z. The genomics of malaria infection. Trends Parasitol. 20, 553–557 (2004).

    Article  CAS  Google Scholar 

  12. Childs, B. Genetic Medicine: A Logic of Disease (Johns Hopkins Univ. Press, Baltimore, 1999).

    Google Scholar 

  13. Guttmacher, A. E., Collins, F. S. & Drazen, J. M. (eds) Genomic Medicine (Johns Hopkins Univ. Press, Baltimore, 2004).

    Google Scholar 

  14. Suther, S. & Goodson, P. Barriers to the provision of genetic services by primary care physicians: a systematic review of the literature. Genet. Med. 5, 70–76 (2003).

    Article  Google Scholar 

  15. Finn, C. T. et al. Psychiatric genetics: a survey of psychiatrists' knowledge, attitudes, opinions, and practice patterns. J. Clin. Psychiatry 66, 821–830 (2005).

    Article  Google Scholar 

  16. Baars, M. J. H. et al. Deficient knowledge of genetics relevant for daily practice among medical students nearing graduation. Genet. Med. 7, 295–301 (2005).

    Article  Google Scholar 

  17. Baars, M. J. H., Henneman, L. & ten Kate L. P. Deficiency of knowledge of genetics and genetics tests among general practitioners, gynecologists, and pediatricians: a global problem. Genet. Med. 7, 605–610 (2005).

    Article  Google Scholar 

  18. Harris, R., Challen, K., Benjamin, C. & Harris, H. Genetic education for non-geneticist health professionals. Comm. Genet. 9, 224–226 (2006).

    Google Scholar 

  19. The Royal Society. Personalised medicines: hopes and realities [online], (2005).

  20. Burton, H. Addressing Genetics, Delivering Health: A strategy for advancing the dissemination and application of genetics knowledge throughout our health professions [online], (2003).

    Google Scholar 

  21. Billings, P. R. et al. Ready for genomic medicine? Perspectives of health care decision makers. Arch. Intern. Med. 165, 1917–1919 (2005).

    Article  Google Scholar 

  22. Korf, B. R. Genetics in medical practice: the need for ultimate makeover. Genet. Med. 7, 293–294 (2005).

    Article  Google Scholar 

  23. Hayflick, S. J. & Eiff, P. Will the learners be learned? Genet. Med. 4, 43–44 (2002).

    Article  Google Scholar 

  24. Korf, B. R., Feldman, G. & Wiesner, G. L. Report of the Banbury meeting on training of physicians in medical genetics. Genet. Med. 7, 443–438 (2005).

    Google Scholar 

  25. The Society of Teachers of Family Medicine. Genetics in Primary Care: A Faculty Development Initiative [online], (2003).

  26. Renwick, A. et al. ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nature Genet. 38, 873–875 (2006).

    Article  CAS  Google Scholar 

  27. Johnson, N. et al. Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study. Lancet 366, 1554–1557 (2005).

    Article  CAS  Google Scholar 

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Correspondence to Alan E. Guttmacher.

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DATABASES

OMIM

ataxia telangiectasia

CADASIL

fragile X syndrome

von Hippel–Lindau disease

FURTHER INFORMATION

American Academy of Family Physicians

American College of Medical Genetics

GenEd Project

GeneTests

Genetics in Clinical Practice: A Team Approach

Genetics in Primary Care

Genetics in Your Practice

International Society of Nurses in Genetics

National Coalition for Health Professional Education in Genetics

National Genetics Education and Development Centre

National Human Genome Research Institute

US Surgeon General's Family History Initiative:

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Guttmacher, A., Porteous, M. & McInerney, J. Educating health-care professionals about genetics and genomics. Nat Rev Genet 8, 151–157 (2007). https://doi.org/10.1038/nrg2007

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