Scientific progress in multiple sclerosis (MS) research spanned a number of areas in 2014, including therapeutics, disease classification, risk management, and disease mechanisms. Advances were particularly notable in the field of progressive MS. Altogether, the findings move us one step closer to a better understanding of this complex disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lublin, F. D. et al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology 83, 278–286 (2014).
Villar, L. M. et al. Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis. Ann. Neurol. 76, 231–240 (2014).
Chataway, J. et al. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Lancet 383, 2213–2221 (2014).
Calabresi, P. A. et al. Pegylated interferon β-1a for relapsing–remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol. 13, 657–665 (2014).
Okuda, D. T. et al. Radiologically isolated syndrome: 5-year risk for an initial clinical event. PLoS ONE 9, e90509 (2014).
Plavina, T. et al. Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy. Ann. Neurol. 76, 802–812 (2014).
Spain, R. & Bourdette, D. The radiologically isolated syndrome: look (again) before you treat. Curr. Neurol. Neurosci. Rep. 11, 498–506 (2011).
Schlaeger, R. et al. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann. Neurol. 76, 568–580 (2014).
Azevedo, C. J. et al. In vivo evidence of glutamate toxicity in multiple sclerosis. Ann. Neurol. 76, 269–278 (2014).
Acknowledgements
J.O. holds the Decker Family Transitional Career Development Award from the Multiple Sclerosis Society of Canada.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.O. has received research funding from Genzyme and has received personal compensation for consulting or speaking from Biogen Idec, EMD Serono, Genzyme and Novartis. P.W.O. has received consulting fees and/or grant support from Actelion, Bayer, Biogen Idec, EMD Serono, Genentech, Novartis, Receptos, Roche, Sanofi–Genzyme and Teva.
Rights and permissions
About this article
Cite this article
Oh, J., O'Connor, P. Progress in MS—classification, mechanisms and treatment. Nat Rev Neurol 11, 76–78 (2015). https://doi.org/10.1038/nrneurol.2014.259
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2014.259