Original ResearchFull Report: Clinical—Alimentary TractEfficacy of Dietary Interventions for Inducing Histologic Remission in Patients With Eosinophilic Esophagitis: A Systematic Review and Meta-analysis
Section snippets
Selection of Studies
Source studies were identified by systematically searching in 3 major bibliographic databases (PUBMED, EMBASE, and Scopus) for the period up to June 2013. To this end, a predetermined protocol was used in accordance with the quality of reporting meta-analyses of observational studies in epidemiology.17, 18
Comprehensive search criteria were used to identify articles dealing with dietary treatments for EoE. We consulted the thesauri for MEDLINE (MESH) and EMBASE (EMTREE) using the following
Results
The search strategy yielded 581 references; 481 documents were excluded after examining the title and abstract because they did not fulfill the inclusion criteria. Of the remaining 100 references, 13 abstracts were excluded either because they were subsequently published as full papers or because they had been presented multiple times at different conferences. For the remaining 87 references that were considered to be potentially relevant, the full text was retrieved for detailed evaluation. Of
Discussion
This meta-analysis of 33 published documents demonstrates that dietary treatment is an effective, drug-free therapy for achieving remission of eosinophilic infiltration in EoE patients. Additionally, our results show that the various dietary treatment strategies are associated with varied efficacy rates, ranging from 90.8% for elemental diets to 45.5% for allergy testing–directed food elimination.
Exclusive feeding with an elemental diet, which was first used in 1995,15 has been assessed in 429
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This article has an accompanying continuing medical education activity on page e13. Learning Objective: Upon completion of this questionnaire, successful learners will be able to distinguish the different dietary therapies used in the treatment of EoE, identify remission rates of each dietary options and recognize some important methodological aspects of systematic reviews and meta-analyses.
Conflicts of interest The authors disclose no conflicts.