American Association of Endocrine SurgeonsLeft ventricular systolic and diastolic function and exercise testing in primary hyperparathyroidism—effects of parathyroidectomy*,**,★
Section snippets
Materials and methods
Thirty consecutive patients with HPT were collected from the referrals for parathyroid operation at the County Hospital of Sundsvall, Sweden. They consisted of 23 women and 7 men, and the overall age range was 33 to 80 years (Table I).The total serum calcium concentration was 2.7 to 3.9 mmol/L (mean, 2.97 ± 0.04 mmol/L; normal range, 2.20 to 2.60 mmol/L) and the intact serum PTH was 5.4 to 48.9 pmol/L (mean, 15.7 ± 1.7 pmol/L; normal range, 1.2-5.7 pmol/L). With random sampling from the
Results
Patients had significantly higher blood calcium and PTH values than the controls at enrollment, while there were no such differences when compared with the controls in the other biochemical variables, body mass index, or body surface area (Table I). All the patients became normocalcemic (mean serum calcium, 2.35 ± 0.02 mmol/L) at the 1-year follow-up, when there were significant reductions in serum calcium, PTH, and alkaline phosphatase values. The total wet weight of the excised, abnormal
Discussion
The current study shows that sporadic primary HPT is associated with hitherto unrecognized cardiovascular abnormalities, which include exercise-related rises in blood pressure, an increased number of ventricular extrasystoles, ST-segment depression, and impaired diastolic LV functions at rest. It should be emphasized that the material consisted of consecutive patients recruited in the clinical routine, who generally had biochemically unequivocal signs of HPT, rather large parathyroid adenomas,
Acknowledgements
We thank Peter Wessman, Mid Sweden Research and Development Center, for statistical advice.
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2017, International Journal of CardiologyCitation Excerpt :However, Kepez et al. reported no significant difference in coronary artery calcification scores between patients with pHPT and age-gender-matched controls [21]. Similarly, several studies assessing left ventricular ejection fraction found no significant difference between pHPT patients and the general population [22–25]. An increased incidence of left ventricular hypertrophy, on the other hand, has been reported among the pHPT population [26–30].
Primary Hyperparathyroidism
2015, Endocrinology: Adult and PediatricNon-traditional Manifestations of Primary Hyperparathyroidism
2015, The Parathyroids: Basic and Clinical Concepts: Third Edition
- *
Supported by the Swedish Medical Research Council.
- **
Reprint requests: Inga-Lena Nilsson, MD, Department of Surgery, Sundsvall Hospital, S-851 86 Sundsvall, Sweden.
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Surgery 2000;128:895-902.