Chest
Original ResearchCritical CareNoninvasive Ventilation in COPD: Impact of Inspiratory Pressure Levels on Sleep Quality
Section snippets
Materials and Methods
The study protocol was approved by the Ethics Committee at the Albert-Ludwigs University, Freiburg, Germany, and was performed in accordance with the ethical standards laid down in the Declaration of Helsinki. Informed, written consent was obtained from all subjects.
Results
Seventeen patients were consecutively enrolled in the study. Four patients dropped out (Fig 1). One patient in period one and three patients in period two refused to sleep under LI-NPPV because of fear of asphyxia. Data are presented for the full analysis set consisting of the 13 patients who completed both treatments in the crossover setting. Demographic data, ventilator settings for HI-NPPV, lung function parameters, and daytime blood gases with supplemental oxygen are shown in Table 1. Mean
Discussion
This is the first randomized crossover trial, to our knowledge, to compare the effects of different forms of NPPV (HI-NPPV vs LI-NPPV) on sleep quality in patients with chronic hypercapnic respiratory failure due to COPD. Two main findings are reported and discussed.
First, sleep quality was comparable between HI-NPPV and LI-NPPV. This also pertained to arousals, suggesting that a reduction in IPAP does not result in an improvement in sleep quality. Although the most recently published trial
Acknowledgments
Author contributions: Dr Dreher: contributed to the planning, data collection, data analysis, and writing of the manuscript.
Dr Ekkernkamp: contributed to the data collection and writing of the manuscript.
Dr Walterspacher: contributed to the data collection and writing of the manuscript.
Dr Walker: contributed to the data collection and writing of the manuscript.
Dr Schmoor: contributed to the statistical analysis of the data and writing of the manuscript.
Dr Storre: contributed to the data
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Cited by (0)
Drs Storre and Windisch contributed equally to this work.
Funding/Support: The study was supported by the German Interdisciplinary Society of Home Mechanical Ventilation (Deutsche Interdisziplinäre Gesellschaft für Außerklinische Beatmung, DIGAB). The study group received an open research grant from Breas Medical AB (Molnlycke, Sweden), Respironics Inc (Pittsburgh, PA), and ResMed GmbH and Co KG (Germany).
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).