Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Complete Adrenocorticotropin Deficiency after Radiation Therapy for Brain Tumor with a Normal Growth Hormone Reserve
Haruna SAKAI, Katsunobu YOSHIOKA, Keiko YAMAGAMI, Tetsuya YAMAKITA, Masayuki HOSOI, Tomofusa ISHII, Toshihiko SATO, Shiro TANAKA, Yoshiyasu IWAI, Satoru FUJII
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Keywords: cranial radiation, endocrinological disturbance, neurofibromatosis type 1
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2002 Volume 41 Issue 6 Pages 453-457

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Abstract

A 34-year-old man with neurofibromatosis type 1, who had received radiation therapy after the excision of a brain tumor 5 years earlier, was admitted to our hospital with vomiting and weight loss. Cortisol and adrenocorticotropin (ACTH) were undetectable before and after administration of 100 μg corticotropin releasing hormone. The level of growth hormone without stimulation was 24.7 ng/ml. We diagnosed him to have complete ACTH deficiency attributable to radiation therapy. This is the first known case of a patient with complete ACTH deficiency after radiation therapy and a growth hormone reserve that remained normal.
(Internal Medicine 41: 453-457, 2002)

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