Abstract
Glycyrrhetinic acid, the active constituent of liquorice, inhibits renal IIbeta-hydroxysteroid dehydrogenase. This allows cortisol to stimulate mineralocorticoid receptors, which can result in hypertension and hypokalaemia. Treatment options are based on pathophysiological understanding.
MeSH terms
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11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
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Candy / toxicity
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Glycyrrhetinic Acid / toxicity*
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Glycyrrhiza / chemistry
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Glycyrrhiza / toxicity
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Humans
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Hypertension / chemically induced*
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Hypertension / enzymology
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Hypokalemia / chemically induced*
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Hypokalemia / enzymology
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Receptors, Mineralocorticoid / drug effects*
Substances
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Receptors, Mineralocorticoid
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11-beta-Hydroxysteroid Dehydrogenases
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Glycyrrhetinic Acid