Lymphocytic meningitis: incidence, causes and outcomes over five years

Ir Med J. 2005 Nov-Dec;98(10):238-40.

Abstract

Over a five-year period 114 cases of lymphocytic meningitis were admitted to a general hospital. Case notes were reviewed to determine incidence, causes and outcomes and to identify what clinical features, cerebrospinal fluid (CSF) parameters or other tests were useful in elucidating a cause. Of 114 patients with lymphocytic meningitis 44 had viral meningitis, six viral encephalitis, and seven had other infective meningo-encephalitis. Seven patients had carcinomatous meningitis, nine had an autoimmune/inflammatory process, thirteen had a demyelinating central nervous system (CNS) disorder, and two had an inflammatory neuropathy. In 26 patients no diagnosis was reached. Six of these showed clear steroid responsiveness. Overall lymphocytic meningitis had a good prognosis. Clinical and CSF characteristics were important in diagnosis and prognosis. Recommendations on management of these cases are presented.

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Humans
  • Incidence
  • Ireland / epidemiology
  • Lymphocytic Choriomeningitis / epidemiology*
  • Lymphocytic Choriomeningitis / etiology*
  • Lymphocytic Choriomeningitis / therapy*
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care*
  • Retrospective Studies