An unusual case of warfarin-induced pinna skin necrosis

J Laryngol Otol. 2009 Jun;123(6):685-8. doi: 10.1017/S0022215108003903. Epub 2008 Oct 17.

Abstract

Introduction: Warfarin-induced skin necrosis is a rare but recognised complication of this drug. The condition predominantly affects the breasts, buttocks and thighs of obese, peri-menopausal women. We present the case of a patient with the condition in an unusual site, and we discuss the management challenges involved.

Case report: An 82-year-old man presented to the ENT department with a diagnosis of pinna haematoma. There was no history of trauma or infection. The patient was taking warfarin long-term for recurrent deep vein thrombosis. Two weeks prior to admission, the patient had had a loading course of warfarin following surgery. Multiple clinical teams were involved in treatment. The only abnormal laboratory investigation was a low protein S level; biopsy showed skin necrosis.

Conclusion: In this case, the unusual presentation created diagnostic confusion, and may have precipitated aggressive surgical debridement. However, a more conservative management strategy was used, which we would recommend in future.

MeSH terms

  • Aged, 80 and over
  • Anticoagulants / adverse effects*
  • Ear Auricle / pathology*
  • Humans
  • Male
  • Necrosis / chemically induced
  • Skin / pathology*
  • Skin Diseases / chemically induced*
  • Warfarin / adverse effects*

Substances

  • Anticoagulants
  • Warfarin