Can lithium or valproate untie tangles in Alzheimer's disease?

J Clin Psychiatry. 2009 Jun;70(6):919-21. doi: 10.4088/jcp.09com05331.
No abstract available

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / pathology
  • Anticonvulsants / adverse effects
  • Anticonvulsants / therapeutic use*
  • Brain / drug effects
  • Brain / pathology
  • Enzyme Inhibitors / adverse effects
  • Enzyme Inhibitors / therapeutic use*
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors
  • Humans
  • Lithium Carbonate / adverse effects
  • Lithium Carbonate / therapeutic use*
  • Neurofibrillary Tangles / drug effects
  • Neurofibrillary Tangles / pathology
  • Phosphorylation / drug effects
  • Plaque, Amyloid / drug effects
  • Plaque, Amyloid / pathology
  • Randomized Controlled Trials as Topic
  • Valproic Acid / adverse effects
  • Valproic Acid / therapeutic use*
  • tau Proteins / drug effects

Substances

  • Anticonvulsants
  • Enzyme Inhibitors
  • MAPT protein, human
  • tau Proteins
  • Lithium Carbonate
  • Valproic Acid
  • Glycogen Synthase Kinase 3