Clonal analysis of erythroid progenitors suggests that pegylated interferon alpha-2a treatment targets JAK2V617F clones without affecting TET2 mutant cells

Leukemia. 2010 Aug;24(8):1519-23. doi: 10.1038/leu.2010.120. Epub 2010 Jun 3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA-Binding Proteins / genetics*
  • Dioxygenases
  • Erythroid Precursor Cells / cytology
  • Erythroid Precursor Cells / enzymology*
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use*
  • Janus Kinase 2 / genetics*
  • Mutation*
  • Polyethylene Glycols / therapeutic use*
  • Proto-Oncogene Proteins / genetics*
  • Recombinant Proteins

Substances

  • DNA-Binding Proteins
  • Interferon alpha-2
  • Interferon-alpha
  • Proto-Oncogene Proteins
  • Recombinant Proteins
  • Polyethylene Glycols
  • Dioxygenases
  • TET2 protein, human
  • Janus Kinase 2
  • peginterferon alfa-2a