The use of dabigatran in elderly patients

Arch Intern Med. 2011 Jul 25;171(14):1285-6. doi: 10.1001/archinternmed.2011.314.

Abstract

Recent approval by the US Food and Drug Administration (FDA) of dabigatran etexilate, an oral direct thrombin inhibitor, for the prevention of stroke in patients with atrial fibrillation will likely extend its administration in elderly patients. The risk of major overdosage of dabigatran etexilate in this population is, however, much increased owing to frequent renal function impairment, low body weight, drug interactions that cannot be detected with a routine coagulation test, and no antagonist available. We report herein 2 clinical cases, including 1 fatal case, illustrating our concern regarding the risk of bleeding events in elderly patients.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged, 80 and over
  • Anticoagulants / adverse effects
  • Anticoagulants / blood
  • Antithrombins / administration & dosage
  • Antithrombins / adverse effects*
  • Antithrombins / blood*
  • Atrial Fibrillation / complications
  • Benzimidazoles / administration & dosage
  • Benzimidazoles / adverse effects*
  • Benzimidazoles / blood*
  • Dabigatran
  • Device Removal
  • Fatal Outcome
  • Female
  • Gastrointestinal Hemorrhage / blood
  • Gastrointestinal Hemorrhage / chemically induced*
  • Gastrointestinal Hemorrhage / complications
  • Humans
  • Pyridines / administration & dosage
  • Pyridines / adverse effects*
  • Pyridines / blood*
  • Shock, Hemorrhagic / blood
  • Shock, Hemorrhagic / etiology*
  • Stroke / etiology
  • Stroke / prevention & control*

Substances

  • Anticoagulants
  • Antithrombins
  • Benzimidazoles
  • Pyridines
  • Dabigatran