The ebbs and flows in the development of cholesterol-lowering drugs: prospects for the future

Clin Pharmacol Ther. 2014 Jul;96(1):64-73. doi: 10.1038/clpt.2014.76. Epub 2014 Apr 3.

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and its prevalence is increasing worldwide. Statins are the mainstay of treatment but do not address all aspects of CVD risk. Other lipid-lowering therapies are available but are less effective than statins. New therapies to lower low-density-lipoprotein cholesterol (LDL-C) by as much as statins, to reduce triglycerides (TGs), and to modify the metabolism of high-density lipoproteins (HDLs) are in development.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / pharmacology
  • Anticholesteremic Agents / therapeutic use*
  • Bile Acids and Salts / metabolism
  • Cardiovascular Diseases / prevention & control
  • Carrier Proteins / antagonists & inhibitors
  • Cholesterol Ester Transfer Proteins / antagonists & inhibitors
  • Cholesterol, LDL / metabolism
  • Fibric Acids / therapeutic use
  • Genetic Therapy
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Lipoproteins, HDL / metabolism
  • Oligonucleotides, Antisense / therapeutic use
  • Peroxisome Proliferator-Activated Receptors / agonists
  • Proprotein Convertase 9
  • Proprotein Convertases / antagonists & inhibitors
  • Proprotein Convertases / genetics
  • Serine Endopeptidases / genetics
  • Triglycerides / metabolism

Substances

  • Antibodies, Monoclonal
  • Anticholesteremic Agents
  • Bile Acids and Salts
  • Carrier Proteins
  • Cholesterol Ester Transfer Proteins
  • Cholesterol, LDL
  • Fibric Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lipoproteins, HDL
  • Oligonucleotides, Antisense
  • Peroxisome Proliferator-Activated Receptors
  • Triglycerides
  • microsomal triglyceride transfer protein
  • PCSK9 protein, human
  • Proprotein Convertase 9
  • Proprotein Convertases
  • Serine Endopeptidases