Microbiome manipulation with faecal microbiome transplantation as a therapeutic strategy in Clostridium difficile infection

B H Mullish; J R Marchesi; M R Thursz; H R T Williams

doi:10.1093/qjmed/hcu182

Microbiome manipulation with faecal microbiome transplantation as a therapeutic strategy in Clostridium difficile infection

QJM. 2015 May;108(5):355-9. doi: 10.1093/qjmed/hcu182. Epub 2014 Sep 4.

Authors

B H Mullish¹, J R Marchesi², M R Thursz², H R T Williams²

Affiliations

¹ From the Section of Hepatology and Gastroenterology, Faculty of Medicine, St Mary's Hospital, Imperial College London, London, UK b.mullish@imperial.ac.uk.
² From the Section of Hepatology and Gastroenterology, Faculty of Medicine, St Mary's Hospital, Imperial College London, London, UK.

Abstract

Faecal microbiome transplantation (FMT) has generated huge recent interest as it presents a potential solution to a significant clinical problem--the increasing incidence of Clostridium difficile infection (CDI). In the short term, however, there remain many practical questions regarding its use, including the optimal selection of donors, material preparation and the mechanics of delivery. In the longer term, enhanced understanding of the mechanisms of action of FMT may potentiate novel therapies, such as targeted manipulation of the microbiome in CDI and beyond.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Clostridioides difficile / pathogenicity*
Clostridium Infections / therapy*
Donor Selection
Fecal Microbiota Transplantation* / adverse effects
Humans
Microbiota*