To recognise and respond to pathogens, germ-line encoded pattern recognition receptors (PRRs)
bind to conserved microbial structures and activate host defence systems, including …

A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes
intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient …

Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by
their differential expression of pattern recognition receptors (PRRs). C‐type lectin receptors (…

The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described
that could mediate its own intracellular signalling. It was initially identified as important for …

Background Treatment of latent Mycobacterium tuberculosis infection is an essential component
of tuberculosis control and elimination. The current standard regimen of isoniazid for 9 …

Recognition of microbial components by germ‐line encoded pattern recognition receptors (PRR)
initiates immune responses to infectious agents. We and others have proposed that …

Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …

Allergen inhalation tests with ragweed pollen extract were performed in 15 ragweed-allergic
asthmatic subjects. Isolated early asthmatic responses were induced in 6 subjects, dual (…

The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an
innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 …

Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP.
Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing …