Exercise and the heart: the good, the bad, and the ugly

S Sharma, A Merghani, L Mont - European heart journal, 2015 - academic.oup.com
The benefits of exercise are irrefutable. Individuals engaging in regular exercise have a
favourable cardiovascular risk profile for coronary artery disease and reduce their risk of …

The U-shaped relationship between exercise and cardiac morbidity

A Merghani, A Malhotra, S Sharma - Trends in cardiovascular medicine, 2016 - Elsevier
Exercise confers a plethora of health benefits that are well documented, whereas physical
inactivity is a leading risk factor for cardiovascular morbidity and mortality. The dose of …

Etiology of sudden death in sports: insights from a United Kingdom regional registry

…, AK Steriotis, M Tome, G Mellor, A Merghani… - Journal of the American …, 2016 - jacc.org
Background : Accurate knowledge of causes of sudden cardiac death (SCD) in athletes and
its precipitating factors is necessary to establish preventative strategies. Objectives : This …

Annexin-1 modulates T-cell activation and differentiation

F D'Acquisto, A Merghani, E Lecona, G Rosignoli… - Blood, 2007 - ashpublications.org
Annexin-1 is an anti-inflammatory protein that plays an important homeostatic role in innate
immunity; however, its potential actions in the modulation of adaptive immunity have never …

Prevalence of subclinical coronary artery disease in masters endurance athletes with a low atherosclerotic risk profile

A Merghani, V Maestrini, S Rosmini, AT Cox, H Dhutia… - Circulation, 2017 - Am Heart Assoc
Background: Studies in middle-age and older (masters) athletes with atherosclerotic risk
factors for coronary artery disease report higher coronary artery calcium (CAC) scores …

Anterior T-wave inversion in young white athletes and nonathletes: prevalence and significance

…, H Dores, R Bastiaenen, R Narain, A Merghani… - Journal of the American …, 2017 - jacc.org
Background : Anterior T-wave inversion (ATWI) on electrocardiography (ECG) in young white
adults raises the possibility of cardiomyopathy, specifically arrhythmogenic right ventricular …

Myocardial native T1 and extracellular volume with healthy ageing and gender

…, AN Bhuva, V Culotta, A Merghani… - European Heart …, 2018 - academic.oup.com
Aims To determine how native myocardial T1 and extracellular volume (ECV) change with
age, both to understand aging and to inform on normal reference ranges. Methods and results …

Impaired T cell activation and increased Th2 lineage commitment in Annexin‐1‐deficient T cells

…, ALF Sampaio, A Merghani… - European journal of …, 2007 - Wiley Online Library
Annexin‐1 is a well‐known endogenous anti‐inflammatory protein that modulates the
activation of cells of the innate immune system such as neutrophils and macrophages. We have …

Cost implications of using different ECG criteria for screening young athletes in the United Kingdom

H Dhutia, A Malhotra, V Gabus, A Merghani… - Journal of the American …, 2016 - jacc.org
Background : High false-positive rates and cost of additional investigations are an obstacle
to electrocardiographic (ECG) screening of young athletes for cardiac disease. However, …

Differentiation between athlete's heart and dilated cardiomyopathy in athletic individuals

…, H Dhutia, A Malhotra, A Merghani… - Heart, 2020 - heart.bmj.com
Objective Distinguishing early dilated cardiomyopathy (DCM) from physiological left ventricular
(LV) dilatation with LV ejection fraction <55% in athletes (grey zone) is challenging. We …