A major diagnostic intervention in the consideration of many patients suspected to have primary
immunodeficiency diseases (PIDDs) is the application and interpretation of vaccination. …

Inherited retinal disease is a common cause of visual impairment and represents a highly
heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals …

Background As of November 2020, severe acute respiratory syndrome coronavirus 2 has
resulted in 55 million infections worldwide and more than 1.3 million deaths from coronavirus …

Synovial T cells in rheumatoid arthritis are highly differentiated and express a phenotype
suggesting susceptibility to apoptosis (CD45RB dull, CD45RO bright, Bcl-2 low, Bax high, Fas …

BACKGROUND: Severe allergic rhinitis uncontrolled by pharmacotherapy can adversely affect
quality of life. Both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (…

Severe allergic rhinitis uncontrolled by conventional medication can substantially affect quality
of life. Immunotherapy involves administering increasing doses of a specific allergen, with …

Background The genetic cause of primary immunodeficiency disease (PID) carries prognostic
information. Objective We conducted a whole-genome sequencing study assessing a …

Neutrophil extracellular traps (NETs) comprise extracellular chromatin and granule protein
complexes that immobilize and kill bacteria.NET release represents a recently discovered, …

A proportion of people living with common variable immunodeficiency disorders develop
granulomatous-lymphocytic interstitial lung disease (GLILD). We aimed to develop a …

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. …