User profiles for Aarnoud P Huissoon
 | Aarnoud P HuissoonImmunology, Birmingham Heartlands Hospital, UK Verified email at uhb.nhs.uk Cited by 6884 |
Inhibition of T cell apoptosis in the rheumatoid synovium.
…, D Scheel-Toellner, AP Huissoon… - The Journal of …, 1997 - Am Soc Clin Investig
Synovial T cells in rheumatoid arthritis are highly differentiated and express a phenotype
suggesting susceptibility to apoptosis (CD45RB dull, CD45RO bright, Bcl-2 low, Bax high, Fas …
suggesting susceptibility to apoptosis (CD45RB dull, CD45RO bright, Bcl-2 low, Bax high, Fas …
[HTML][HTML] British Lung Foundation/United Kingdom Primary Immunodeficiency Network consensus statement on the definition, diagnosis, and management of …
…, R Herriot, RK Hoyles, AP Huissoon… - The Journal of Allergy …, 2017 - Elsevier
A proportion of people living with common variable immunodeficiency disorders develop
granulomatous-lymphocytic interstitial lung disease (GLILD). We aimed to develop a …
granulomatous-lymphocytic interstitial lung disease (GLILD). We aimed to develop a …
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
…, A Herwadkar, N Cooper, S Grigoriadou, AP Huissoon… - Nature, 2020 - nature.com
Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. …
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. …
Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations
…, A Herwadkar, F Hu, S Hughes, AP Huissoon… - Journal of Allergy and …, 2020 - Elsevier
Background An increasing number of NFKB1 variants are being identified in patients with
heterogeneous immunologic phenotypes. Objective To characterize the clinical and cellular …
heterogeneous immunologic phenotypes. Objective To characterize the clinical and cellular …
[HTML][HTML] Biomarkers in human anaphylaxis: a critical appraisal of current evidence and perspectives
…, T Wilding, RJ Buka, RL Baretto, AP Huissoon… - Frontiers in …, 2019 - frontiersin.org
Anaphylaxis is a type I hypersensitivity reaction that is potentially fatal if not promptly treated.
It is a clinical diagnosis, although measurement of serial serum total mast cell tryptase (MCT…
It is a clinical diagnosis, although measurement of serial serum total mast cell tryptase (MCT…
Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man
…, AP Huissoon, DS Kumararatne, J Martin, P O'Leary… - The Lancet, 2004 - thelancet.com
Background Individuals who chronically excrete neurovirulent poliovirus of vaccine-origin are
of considerable concern to the Global Polio Eradication programme. Chronic infection with …
of considerable concern to the Global Polio Eradication programme. Chronic infection with …
[HTML][HTML] Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI
…, SJ Montague, H Clifford, AP Huissoon… - …, 2018 - ncbi.nlm.nih.gov
Ibrutinib and acalabrutinib are irreversible inhibitors of Bruton tyrosine kinase used in the
treatment of B-cell malignancies. They bind irreversibly to cysteine 481 of Bruton tyrosine …
treatment of B-cell malignancies. They bind irreversibly to cysteine 481 of Bruton tyrosine …
[HTML][HTML] Low-dose Btk inhibitors selectively block platelet activation by CLEC-2
…, S Watson, CN Watson, H Clifford, AP Huissoon… - …, 2021 - ncbi.nlm.nih.gov
Inhibitors of Bruton tyrosine kinase (Btk) have been proposed as novel antiplatelet agents.
In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-…
In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-…
T-cell abnormalities in common variable immunodeficiency: the hidden defect
GK Wong, AP Huissoon - Journal of clinical pathology, 2016 - jcp.bmj.com
This review discusses how the T-cell compartment in common variable immunodeficiency is
marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune …
marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune …
Anaphylaxis and clinical utility of real-world measurement of acute serum tryptase in UK emergency departments
…, RJ Crossman, CL Melchior, AP Huissoon… - The Journal of Allergy …, 2017 - Elsevier
Background British guidelines recommend that serial acute serum tryptase measurements
be checked in all adults and a subset of children presenting with anaphylaxis. This is the first …
be checked in all adults and a subset of children presenting with anaphylaxis. This is the first …