One long-standing approach for improving transdermal drug delivery uses penetration
enhancers (also called sorption promoters or accelerants) which penetrate into skin to reversibly …

Abuse of 4-propyloxy-4-phenyl-N-methylpiperidine, a meperidine congener, produced
parkinsonism in a 23-year-old man. Unlike other drug-induced motor disturbances, the syndrome …

Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical
practice, either in primary or in secondary care, and are frequently missed during routine …

Non‐motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce
quality of life and at present there is no validated clinical tool to assess the progress or …

A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase
Syndrome and Extreme Diurnal Preference Page 1 INTRODUCTION SLEEP TIMING AND …

Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in
aqueous solutions at pH < 6.5. It has been widely used for developing drug delivery systems …

Background Surgical intervention for advanced Parkinson's disease is an option if medical
therapy fails to control symptoms adequately. We aimed to assess whether surgery and best …

This paper reports interactions and possible incompatibilities in solid dispersions of
hydrophobic drugs with hydrophilic carriers, with solubility parameters employed as a means of …

2006, there was, no single instrument (questionnaire or scale) for attempting a comprehensive
assessment of the wide range of nonmotor symptoms (NMS) of Parkinson's disease (PD). …

A series of terpenes has been assessed as skin penetration enhancers towards the model
polar penetrant 5-fluorouracil (5-FU). Cyclic terpenes were selected from the chemical …