Background We aimed to evaluate the use of baricitinib, a Janus kinase (JAK) 1–2 inhibitor,
for the treatment of patients admitted to hospital with COVID-19. Methods This randomised, …

Background Low-dose corticosteroids have been shown to reduce mortality for patients with
COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, …

Background The frequency rates of mutations such as KRAS, NRAS, BRAF, and PIK3CA in
colorectal cancer (CRC) differ among populations. The aim of this study was to assess …

Data access latency, a limiting factor in the performance of chip multiprocessors, grows
significantly with the number of cores in non-uniform cache architectures with distributed cache …

In chip-multiprocessors (CMPs) the network-on-chip (NoC) carries cache coherence and
data messages. These messages may be classified into critical and non-critical messages. …

This work explores a method for efficient pre-allocation of circuits in network-on-chip (NoC)
to reduce communication latency and improve performance. Circuit pre-allocation eliminates …

Reducing data access latency is vital to achieving performance improvements in computing.
For chip multiprocessors (CMPs), data access latency depends on the organization of the …

Fast and accurate performance analysis techniques are essential in early design space
exploration and pre-silicon evaluations, including software eco-system development. In particular…

This paper introduces a predictive modeling framework to estimate the performance of GPUs
during pre-silicon design. Early-stage performance prediction is useful when simulation …

In chip multiprocessors (CMPs), on-chip interconnect carries data and coherence traffic
exchanged between on chip cache banks. Reducing communication latency is critical for …