Hepatocellular carcinoma (HCC), the most common liver cancer, occurs mainly in men.
Similar gender disparity is seen in mice given a chemical carcinogen, diethylnitrosamine (DEN). …

Nuclear factor‐κB (NF‐κB) is a transcriptional regulator of genes involved in immunity,
inflammatory response, cell fate, and function. Recent attention has focused on the …

Background & Aims Acute decompensation (AD) of cirrhosis is defined as the acute
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any …

We investigated whether ancestral liver damage leads to heritable reprogramming of hepatic
wound healing in male rats. We found that a history of liver damage corresponds with …

Background & Aims Acute decompensation (AD) of cirrhosis may present without acute-on-chronic
liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(…

The introduction of efficacious new hepatitis C virus (HCV) treatments galvanized the World
Health Organization to define ambitious targets for eliminating HCV as a public health threat …

BACKGROUND & AIMS: The pro-inflammatory functions of NF-κB must be tightly regulated
to prevent inappropriate tissue damage and remodelling caused by activated inflammatory …

Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …

Severe alcoholic hepatitis (sAH) is associated with a poor prognosis. There is no proven
effective treatment for sAH, which is why early transplantation has been increasingly discussed. …

Background Ribavirin is currently recommended for treating chronic hepatitis E virus (HEV)
infection. This retrospective European multicenter study aimed to assess the sustained …