Objective To ascertain the current burden of adverse drug reactions (ADRs) through a prospective
analysis of all admissions to hospital. Design Prospective observational study. Setting …

Methods We conducted a search on the BIDS ISI database between 1981 and 1997 using
key words such as toxicity and hypersensitivity combined with drug. The references most …

Drug regulatory agencies should ensure that the benefits of drugs outweigh their risks, but
licensed medicines sometimes do not perform as expected in everyday clinical practice. …

Background Intermittent preventive treatment (IPT) is a promising strategy for malaria
control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) …

Drug regulatory agencies are increasingly pressed by the challenge of finding the
appropriate balance between the need for rapid access to new drugs and the need to ensure …

Drug repurposing has been proposed as a strategy to develop new therapies that has fewer
risks, lower costs and shorter timelines than developing completely new drugs. However, …

Objective: The most important hepatic enzyme involved in the metabolism of protease inhibitors
is cytochrome P450 3A4 (CYP3A4). Ritonavir (RIT) is a potent inhibitor of CYP3A4 and …

Drugs are approved by regulatory agencies on the basis of their assessment of whether the
available evidence indicates that the benefits of the drug outweigh its risks. In recent years, …

… Alasdair Breckenridge, … Alasdair Breckenridge, … Citation: Eichler HG, Abadie E,
Breckenridge A, Leufkens H, Rasi G (2012) Open Clinical Trial Data for All? A View from …

A rational strategy for chemotherapy demands that dosage schedules be based on an
adequate knowledge of clinical and biochemical pharmacology. Many anthelmintic drugs (eg …