User profiles for Alex Hoffman

Alexander F. Hoffman, Ph.D.

National Institutes of Health, National Institute on Drug Abuse Intramural Research Program
Verified email at intra.nida.nih.gov
Cited by 6964

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

BJ Hoffer, A Hoffman, K Bowenkamp, P Huettl… - Neuroscience …, 1994 - Elsevier
Fischer 344 rats were unilaterally injected into the medial forebrain bundle with 6-hydroxydopamine
(6-OHDA). Apomorphine-induced rotational behavior was used to select animals …

Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo

…, AC Granholm, GA Gerhardt, MA Henry, A Hoffman… - Brain research …, 1995 - Elsevier
Recently, a novel glial cell line-derived neurotrophic factor (GDNF) has been identified,
cloned, and shown to have potent survival- and growth-promoting activity on fetal rat midbrain …

Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss)

PN Fitzsimmons, JD Fernandez, AD Hoffman… - Aquatic toxicology, 2001 - Elsevier
The branchial elimination of pentachloroethane and four congeneric polychlorinated biphenyls
by rainbow trout was measured using a fish respirometer-metabolism chamber and an …

Can a novel clinical risk score improve pneumonia prediction in acute stroke care? A UK multicenter cohort study

CJ Smith, BD Bray, A Hoffman, A Meisel… - Journal of the …, 2015 - Am Heart Assoc
Background Pneumonia frequently complicates stroke and has a major impact on outcome.
We derived and internally validated a simple clinical risk score for predicting stroke‐…

Mechanisms of cannabinoid inhibition of GABAASynaptic transmission in the hippocampus

AF Hoffman, CR Lupica - Journal of Neuroscience, 2000 - Soc Neuroscience
The localization of cannabinoid (CB) receptors to GABAergic interneurons in the hippocampus
indicates that CBs may modulate GABAergic function and thereby mediate some of the …

[HTML][HTML] Powerful cocaine-like actions of 3, 4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products

…, KR Lehner, EB Thorndike, AF Hoffman… - …, 2013 - nature.com
The abuse of psychoactive ‘bath salts’ containing cathinones such as 3, 4-methylenedioxypyrovalerone
(MDPV) is a growing public health concern, yet little is known about their …

[HTML][HTML] Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England

BD Bray, L Paley, A Hoffman, M James… - The Lancet Public …, 2018 - thelancet.com
Background We aimed to estimate socioeconomic disparities in the incidence of hospitalisation
for first-ever stroke, quality of care, and post-stroke survival for the adult population of …

Evaluation of log KOW and tissue lipid content as predictors of chemical partitioning to fish tissues

SL Bertelsen, AD Hoffman, CA Gallinat… - … and Chemistry: An …, 1998 - Wiley Online Library
In vitro equilibrium chemical partition coefficients were determined for six chemicals in
selected tissues from four species of fish. Log‐transformed values were then regressed in …

The economic burden of stroke care in England, Wales and Northern Ireland: Using a national stroke register to estimate and report patient-level health economic …

…, A Desikan, D Wonderling, A Hoffman… - European stroke …, 2018 - journals.sagepub.com
Introduction Stroke registries are used in many settings to measure stroke treatment and
outcomes, but rarely include data on health economic outcomes. We aimed to extend the …

[HTML][HTML] Associations between stroke mortality and weekend working by stroke specialist physicians and registered nurses: prospective multicentre cohort study

…, J Campbell, GC Cloud, M James, A Hoffman… - PLoS …, 2014 - journals.plos.org
Background Observational studies have reported higher mortality for patients admitted on
weekends. It is not known whether this “weekend effect” is modified by clinical staffing levels …