DNA polymerases change their specificity for nucleotide substrates with each catalytic cycle,
while achieving error frequencies in the range of 10 −5 to 10 −6 . Here we present a 2.2 Å …

A combined experimental and theoretical comparative study of the hydrodeoxygenation (HDO)
of anisole was conducted over Pt, Ru, and Fe metals. In the experimental part, an inert …

We recently reported the discovery of AM-8553 (1), a potent and selective piperidinone
inhibitor of the MDM2–p53 interaction. Continued research investigation of the N-alkyl …

Purpose A Youth Compendium of Physical Activities (Youth Compendium) was developed
to estimate the energy costs of physical activities using data on youth only. Methods On the …

Plato's Meno and Phaedo are two of the most important works of ancient western philosophy
and continue to be studied around the world. The Meno is a seminal work of epistemology. …

Base-excision DNA repair proteins that target alkylation damage act on a variety of seemingly
dissimilar adducts, yet fail to recognize other closely related lesions. The 1.8 Å crystal …

Even as novel technologies emerge and medicines advance, pathogen-transmitting
mosquitoes pose a deadly and accelerating public health threat. Detecting and mitigating the …

More than mountains separate Virginia from West Virginia. Despite sharing a common
history and a common name, the two states have deep cultural differences. Virginia and West …

The article focuses on the use of disabled antiheroes in the television show" Vikings." The
author discusses the reemergence of antiheroes in popular culture, examines the relationship …

Purpose : We report a comparative analysis of a large series of laparoscopic and robotic
partial nephrectomies performed by a high volume single surgeon at a tertiary care institution. …