Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer …

AG Lai, L Pasea, A Banerjee, G Hall, S Denaxas… - BMJ open, 2020 - bmjopen.bmj.com
Objectives To estimate the impact of the COVID-19 pandemic on cancer care services and
overall (direct and indirect) excess deaths in people with cancer. Methods We employed near …

Estimating excess mortality in people with cancer and multimorbidity in the COVID-19 emergency

AG Lai, L Pasea, A Banerjee, S Denaxas, M Katsoulis… - MedRxiv, 2020 - medrxiv.org
Background Cancer and multiple non-cancer conditions are considered by the Centers for
Disease Control and Prevention (CDC) as high risk conditions in the COVID-19 emergency. …

[HTML][HTML] Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 …

…, SH Mueller, S Denaxas, AG Lai - The Lancet Healthy …, 2022 - thelancet.com
Background Randomised controlled trials (RCTs) inform prescription guidelines, but stringent
eligibility criteria exclude individuals with vulnerable characteristics, which we define as …

[HTML][HTML] Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

…, R Joshi, M Katsoulis, R Kumar, AG Lai… - The Lancet Digital …, 2023 - thelancet.com
Background Globally, there is a paucity of multimorbidity and comorbidity data, especially
for minority ethnic groups and younger people. We estimated the frequency of common …

Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic

A Banerjee, S Chen, L Pasea, AG Lai… - European journal of …, 2021 - academic.oup.com
Aims Cardiovascular diseases (CVDs) increase mortality risk from coronavirus infection (COVID-19).
There are also concerns that the pandemic has affected supply and demand of …

The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

D Kao, AG Lai, E Stamataki, S Rosic, N Konstantinides… - elife, 2016 - elifesciences.org
10.7554/eLife.20062.001 The amphipod crustacean Parhyale hawaiensis is a blossoming
model system for studies of developmental mechanisms and more recently regeneration. We …

[HTML][HTML] COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

…, A Akbari, A Banerjee, J Cooper, AG Lai… - The Lancet Digital …, 2022 - thelancet.com
Background Updatable estimates of COVID-19 onset, progression, and trajectories underpin
pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to …

[HTML][HTML] Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health …

…, G Misirli, K Bhaskaran, G Wannamethee… - The Lancet Diabetes & …, 2021 - thelancet.com
Background Targeted obesity prevention policies would benefit from the identification of
population groups with the highest risk of weight gain. The relative importance of adult age, sex, …

[HTML][HTML] Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers

WH Chang, AG Lai - Nature medicine, 2022 - nature.com
Cancer is a life-altering event causing considerable psychological distress. However,
information on the total burden of psychiatric disorders across all common adult cancers and …

[HTML][HTML] EvoRegen in animals: Time to uncover deep conservation or convergence of adult stem cell evolution and regenerative processes

AG Lai, AA Aboobaker - Developmental biology, 2018 - Elsevier
How do animals regenerate specialised tissues or their entire body after a traumatic injury,
how has this ability evolved and what are the genetic and cellular components underpinning …