Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …

Background Etrolizumab is a gut-targeted, anti-β7 integrin, monoclonal antibody. In an earlier
phase 2 induction study, etrolizumab significantly improved clinical remission compared …

Radiation enteritis is defined as the loss of absorptive capacity of the intestine following
irradiation, which is most commonly seen after radiotherapy for pelvic and abdominal …

Background We sought to report the effectiveness of infliximab and adalimumab over the first
3 years of treatment and to define the factors that predict anti-TNF treatment failure and the …

Background Anti‐drug antibodies are associated with treatment failure to anti‐TNF agents in
patients with inflammatory bowel disease (IBD). Aim To assess whether immunogenicity to …

Refeeding problems have been recognised since the the liberation of starved communities
under siege. The main clinical problems may relate to hypophosphataemia, …

The gut microbiome in the inflammatory bowel disease, ulcerative colitis (UC), is different to
that of healthy controls. Patients with UC have relative reductions in abundance of Firmicutes …

… Danbury, consultant in anaesthetics and intensive care, D Charles Foster, fellow, E
Simon Gabe, consultant gastroenterologist, F Andrew Goddard, consultant …

Hepatitis E indigenous to developed countries (hepatitis E IDC ) is a form of hepatitis E in
persons with no travel history to highly endemic areas. It has been recognized recently as an …