Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold
protein in lymphocytes that links antigen receptor engagement with downstream signaling to …

The Resuscitation Council UK has updated its Guideline for healthcare providers on the
Emergency treatment of anaphylaxis. As part of this process, an evidence review was …

Anaphylaxis is a serious systemic hypersensitivity reaction that is usually rapid in onset and
may cause death. It is characterised by the rapid development of airway and/or breathing …

Monitor infusion site regularly to ensure patency of cannula Tachycardia, tremor, pallor with
a normal or raised BP may indicate excessive adrenaline treatment: reduce the infusion rate (…

Long-term humoral autoimmunity to RNA–protein autoantigens is considered a hallmark of
systemic autoimmune diseases. We use high resolution Orbitrap mass spectrometric …

The La/SSB autoantigen is a major target of long-term humoral autoimmunity in primary
Sjögren's Syndrome (SS) and systemic lupus erythematosus. A majority of patients with linked …

Allergy to insects of the family Tabanidae (order Diptera), commonly called horseflies or
deerflies, is anecdotally common, although the published literature is limited to case reports and …

Dr Mahableshwar Albur has received consultancy fees from Pfizer and Shionogi. All the 32
other authors declare that they do not have any financial relationships with biotechnology 33 …

Mastocytosis is a group of heterogeneous conditions characterized by clonal proliferation of
abnormal mast cells in the skin and/or other organs. There are 3 major subforms: cutaneous …

Background CARD11 encodes a scaffold protein in lymphocytes that links antigen receptor
engagement with downstream signaling to NF-κB, JNK, and mTORC1. Germline CARD11 …