microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking

…, M Solomon, A Pincus, A Pilling… - Journal of …, 2014 - Soc Neuroscience
Escalation of voluntary alcohol consumption is a hallmark of alcoholism, but its neural
substrates remain unknown. In rats, escalation occurs following prolonged exposure to cycles of …

GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation

LW Madsen, JA Knauf, C Gotfredsen, A Pilling… - …, 2012 - academic.oup.com
Liraglutide and exenatide are glucagon-like peptide receptor (GLP-1R) agonists used in the
treatment of type 2 diabetes. Both molecules have been associated with the development of …

[HTML][HTML] In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model

E Yaghini, H Turner, A Pilling, I Naasani… - … , biology and medicine, 2018 - Elsevier
Quantum dot (QD) nanoparticles are highly promising contrast agents and probes for
biomedical applications owing to their excellent photophysical properties. However, toxicity …

[HTML][HTML] The GABAB positive allosteric modulator ADX71441 attenuates alcohol self-administration and relapse to alcohol seeking in rats

E Augier, RS Dulman, R Damadzic, A Pilling… - …, 2017 - nature.com
GABAergic signaling is involved in modulating the reinforcing properties of alcohol, and GABA
B receptors have been proposed as a potential target for clinical treatment of alcoholism. …

A comparison of rodent and nonrodent laryngeal and tracheal bifurcation sensitivities in inhalation toxicity studies and their relevance for human exposure

V Mowat, DJ Alexander, AM Pilling - Toxicologic Pathology, 2017 - journals.sagepub.com
In inhalation toxicity studies, drug-induced lesions are frequently reported in the larynx and
sometimes at the tracheal bifurcation (carina) in the rat, but less so in the dog or monkey, …

[HTML][HTML] Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies

E Yaghini, E Tacconi, A Pilling, P Rahman… - European Journal of …, 2021 - Elsevier
There is considerable interest in biomedical applications of quantum dot (QD) nanoparticles,
in particular their use as imaging agents for diagnostic applications. In order to investigate …

Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat

…, K Oakley, N McCormack, A Pilling - Toxicologic …, 2005 - journals.sagepub.com
The aim of this study was to use immunohistochemistry with morphometry to investigate COX-1
and COX-2 expression in the normal rat gastrointestinal (GI) tract and examine if sites of …

The assessment of local tolerance, acute toxicity, and DNA biodistribution following particle-mediated delivery of a DNA vaccine to minipigs

AM Pilling, RM Harman, SA Jones… - Toxicologic …, 2002 - journals.sagepub.com
Particle-mediated DNA delivery was used to administer a DNA vaccine against Hepatitis B
to minipigs. The study represented one arm of the safety evaluation program for this product …

The haemotoxicity of azathioprine in repeat dose studies in the female CD‐1 mouse

…, S McKeag, CVJ Mifsud, AM Pilling… - International journal …, 2008 - Wiley Online Library
Azathioprine (AZA) is a cytotoxic immunosuppressive drug used in the prevention of
rejection in organ transplants and the treatment of auto‐immune diseases. However, AZA is …

[HTML][HTML] What reductions in dependency costs result from treatment in an inpatient neurological rehabilitation unit for people with stroke?

RJ O'Connor, R Beden, A Pilling… - Clinical medicine, 2011 - ncbi.nlm.nih.gov
This paper examines the reductions in care costs that result from inpatient multidisciplinary
rehabilitation for younger people with acquired brain injury. Thirty-five consecutive patients …