In experimental animals, maternal diet during the periconceptional period influences the
establishment of DNA methylation at metastable epialleles in the offspring, with permanent …

Objective: To test the efficacy in terms of birth weight and infant survival of a diet supplement
programme in pregnant African women through a primary healthcare system. Design: 5 …

Severely obese (ob/ob) mice are deficient in the adipocyte-derived hormone leptin, which
acts on the hypothalamus to control appetite and energy expenditure. The administration of …

Thirty years ago international nutritionists were focussing on childhood malnutrition, the ‘protein
gap’ and how to feed the world's burgeoning population, and medical services in the …

Total free living energy expenditure was compared in lean and obese women by the new
doubly labelled water method and partitioned into basal metabolism and thermogenesis plus …

We present evidence that events in early life strongly influence the adult survival prospects
of rural Africans. Our analysis of births and deaths in three Gambian villages dating back to …

Body mass index (BMI) is the cornerstone of the current classification system for obesity and
its advantages are widely exploited across disciplines ranging from international …

The prevalence of clinical obesity in Britain has doubled in the past decade. The Health of
the Nation initiative has set ambitious targets for reversing the trend in recognition of the …

The objective was to develop recommendations for the diagnosis and treatment of endometriosis
and its associated symptoms. A working group was convened comprised of practising …

Fast foods are frequently linked to the epidemic of obesity, but there has been very little
scientific appraisal of a possible causal role. Here we review a series of studies demonstrating …