User profiles for Andrew T Hattersley
 | Professor Andrew HattersleyUniversity of Exeter Verified email at exeter.ac.uk Cited by 147739 |
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…
and 38,987 controls of European descent and following up previously unidentified meta-…
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
…, AD Morris, PJ Donnelly, TM Frayling, AT Hattersley… - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …
we conducted a meta-analysis of genetic variants on the Metabochip, including …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
…, TM Frayling, V Giedraitis, S Hackinger, AT Hattersley… - Nature …, 2018 - nature.com
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …
European-descent individuals (9% cases), after imputation to high-density reference panels. …
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …
[HTML][HTML] Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6. 2 and permanent neonatal diabetes
…, PR Njølstad, FM Ashcroft, AT Hattersley - … England Journal of …, 2004 - Mass Medical Soc
Background Patients with permanent neonatal diabetes usually present within the first three
months of life and require insulin treatment. In most, the cause is unknown. Because ATP-…
months of life and require insulin treatment. In most, the cause is unknown. Because ATP-…
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
…, BG Han, K Hara, N Hassanali, AT Hattersley… - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS), including …
aggregated published meta-analyses of genome-wide association studies (GWAS), including …