Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of …

Background Some high-income countries have deployed fourth doses of COVID-19 vaccines,
but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain. We …

Background The scale of the 2022 global mpox (formerly known as monkeypox) outbreak
has been unprecedented. In less than 6 months, non-endemic countries have reported more …

Background In a parallel-group, international, phase 3 study (ClinicalTrials.gov NCT04762680),
we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein …

An epidemic of cat-transmitted sporotrichosis caused by Sporothrix brasiliensis has emerged
as a major public health threat in Brazil in recent decades. We report the first three cases of …

Objective To describe the characteristics and outcomes of patients with a clinical diagnosis
of COVID-19 and false-negative SARS-CoV-2 reverse transcription-PCR (RT-PCR), and …

Rationale: Platelets may interact with the immune system in tuberculosis (TB) to regulate
human inflammatory responses that lead to morbidity and spread of infection. Objectives: To …

COVID-19 has caused a major global pandemic and necessitated unprecedented public
health restrictions in almost every country. Understanding risk factors for severe disease in …

In tuberculosis (TB), the innate inflammatory immune response drives tissue destruction,
morbidity, and mortality. Monocytes secrete matrix metalloproteinases (MMPs), which have key …

Mycobacterium tuberculosis (M.tb) infection causes marked tissue inflammation leading to
lung destruction and morbidity. The inflammatory extracellular microenvironment is acidic, …