Haemoglobin E (HbE) β-thalassaemia causes approximately 50% of all severe thalassaemia
worldwide; equating to around 30,000 births per year. HbE β-thalassaemia is due to a …

The α-synuclein protein, encoded by SNCA, has a key role in the pathogenesis of Parkinson’s
disease and other synucleinopathies. Although usually sporadic, Parkinson’s disease can …

Key mechanisms of fetal hemoglobin (HbF) regulation and switching have been elucidated
through studies of human genetic variation, including mutations in the HBG1/2 promoters, …

The loss of normal regulation of corticosteroid secretion is important in the development of
cardiovascular disease. We previously showed that microRNAs regulate the terminal stages …

Potential bias introduced during DNA isolation is inadequately explored, although it could
have significant impact on downstream analysis. To investigate this in human brain, we …

For the fabrication of thermoelectric and optoelectronic devices, metal halide perovskite
materials are perfect applicants. In this work, first-principles computation is carried out to explore …

Hemodialysis is a vital management option for end-stage renal disease (ESRD) patients.
With adequate hemodialysis, patients can have a good quality of life but complications do …

Hepatitis B (HBV) is one of the most common infectious diseases, with a worldwide annual
incidence of over 250 million people. About one-third of the cases are in China. While China …

Multiplexed, real-time fluorescence detection at the single-molecule level is highly desirable
to reveal the stoichiometry, dynamics, and interactions of individual molecular species …

Background Venous thromboembolism (VTE) in patients with thrombocytopenia represents
a complex management challenge. Objectives To describe practice, document outcomes, …