The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …
[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
…, S Sakaue, JE Huffman, A Moscati, B Trivedi… - Cell, 2020 - cell.com
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
[HTML][HTML] Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
Individuals with South Asian ancestry have a higher risk of heart disease than other groups
but have been largely excluded from genetic research. Using data from 22,000 British …
but have been largely excluded from genetic research. Using data from 22,000 British …
Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people
…, MI McCarthy, J Robson, B Trivedi… - International journal …, 2020 - academic.oup.com
Hackney, Barking and Dagenham are the 9th, 10th and 11th most deprived local authorities
in England). 5 Compared with White British people, British South Asians living in east …
in England). 5 Compared with White British people, British South Asians living in east …
[HTML][HTML] Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia
RR Taylor, B Trivedi, N Patel, R Singh… - Clinical …, 2021 - ncbi.nlm.nih.gov
Background The COVID-19 pandemic has strained healthcare systems and how best to
address post-COVID health needs is uncertain. Here we describe the post-COVID symptoms of …
address post-COVID health needs is uncertain. Here we describe the post-COVID symptoms of …
[PDF][PDF] A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
…, J Takayama, HC Martin, KA Hunt, B Trivedi… - The American Journal of …, 2022 - cell.com
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic
associations into biological insights. Here, we integrate a large GWAS on blood lipids …
associations into biological insights. Here, we integrate a large GWAS on blood lipids …
[HTML][HTML] Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
…, A Narita, J Takayama, HC Martin, KA Hunt, B Trivedi… - Genome biology, 2022 - Springer
Background Genetic variants within nearly 1000 loci are known to contribute to modulation
of blood lipid levels. However, the biological pathways underlying these associations are …
of blood lipid levels. However, the biological pathways underlying these associations are …
[HTML][HTML] Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
…, HJ Zar, ML Campbell, DA Van Heel, B Trivedi… - Nature Genetics, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted
in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding …
in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding …
Role of sex in atherosclerosis: does sex matter?
B Trivedi, R Desai, K Mishra, LA Hechanova… - Current Cardiology …, 2022 - Springer
Purpose of Review Atherosclerosis is the largest cause of death in the western world with
the role of sex yet to be determined. The purpose of this review is to investigate the role sex …
the role of sex yet to be determined. The purpose of this review is to investigate the role sex …
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistanis and Bangladeshis
Background Individuals with South Asian ancestry have higher risk of heart disease than
other groups in Western countries; however, most genetic research has focused on European-…
other groups in Western countries; however, most genetic research has focused on European-…