Immune checkpoint inhibitors are now widely used in the treatment of multiple cancers. The
major toxicities of these treatments are termed immune related adverse events and …

… Was this what that feeling of bliss had been leading up to? … Previous critics generally seem
to agree that "Bliss" embodies … her growing sense of marital bliss. In accordance with this …

Melt onset (MO) on Arctic sea ice has been monitored using satellite‐based passive
microwave (PMW) observations since 1979. In this work, surface air temperatures from the …

For more than half a century, researchers around the world have been engaged in attempts
to achieve fusion ignition as a proof of principle of various fusion concepts. Following the …

Gossip is a form of affective information about who is friend and who is foe. We show that
gossip does not influence only how a face is evaluated—it affects whether a face is seen in the …

The land ice contribution to global mean sea level rise has not yet been predicted 1 using
ice sheet and glacier models for the latest set of socio-economic scenarios, nor using …

Background Trastuzumab targets the extracellular domain of the HER2 protein. Adding
trastuzumab to chemotherapy for patients with early-stage, HER2-positive breast cancer reduces …

Background For women with early-stage oestrogen receptor (ER)-positive breast cancer,
adjuvant tamoxifen reduces 15-year breast cancer mortality by a third. Aromatase inhibitors are …

Background Increasing the dose intensity of cytotoxic therapy by shortening the intervals
between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose …

Heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs), formed in
temperature and time-dependent manners during cooking of meat, may increase the risk of certain …